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Mashup Score: 7Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience - Nature Biomedical Engineering - 3 year(s) ago
The integration of scalable and modular hardware and software for the remote operation of programmable miniaturized wireless networks allows for the study of the behaviour of large groups of rodents.
Source: Nature Biomedical EngineeringCategories: Latest Headlines, NeurologyTweet
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Mashup Score: 7
The repertoire of new preclinical strategies for fighting tumours that resist or evade immunotherapy drugs and cellular immunotherapies is widening.
Source: Nature Biomedical EngineeringCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @natBME: The strategies of resistance and evasion of malignant tumours are, unfortunately, varied and plenty. https://t.co/zA1O4gSJOs h…
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Mashup Score: 1
Antitumour immune responses to checkpoint blockade can be augmented by modulating the microbiota in the tumour with hydrogel-embedded silver nanoparticles and specific exogenous bacteria, as shown for mice with squamous carcinoma tumours.
Source: Nature Biomedical EngineeringCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Pts with OSCCs containing high levels of Peptostreptococcus bacteria have higher probability of long-term survival. In mouse models incorporating the pts microbiota, biomaterial-mediated modulation of the oral microbiota synergizes with PD-1 blockade: https://t.co/hz5hh8sZIP
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Mashup Score: 9Mining for encrypted peptide antibiotics in the human proteome - Nature Biomedical Engineering - 4 year(s) ago
The human proteome can be algorithmically mined to identify thousands of encrypted peptides, encoded in proteins with biological function unrelated to the immune system, that display antibacterial activity in vivo.
Source: Nature Biomedical EngineeringCategories: Future of Medicine, Latest HeadlinesTweet-
Computational mining of the human proteome uncovers thousands of cryptic peptides with antimicrobial activity. #NBThighlight of work from @delafuenteupenn and colleagues. https://t.co/tgqi9BBa3q
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Mashup Score: 5Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells - Nature Biomedical Engineering - 4 year(s) ago
A bispecific antibody targeting the T-cell co-receptor CD3ε and the immune checkpoint programmed-death ligand 1 on dendritic cells rejuvenates tumour-specific CD8 T cells, leading to durable antitumour responses in murine models of cancer.
Source: Nature Biomedical EngineeringCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Study demonstrates rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells (DCs), but not tumour cells, via promotion of T cell co-stimulation by B7-1/B7-2 on DCs: https://t.co/APGTlx3o18 #ImmunoOnc
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Mashup Score: 6
The concurrent depletion of tumour cells and immunosuppressive cells via a monoclonal antibody targeting a common surface marker prevents tumours from acquiring resistance to therapies involving immune checkpoint blockade.
Source: Nature Biomedical EngineeringCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Preclinical study shows that an anti-CD73 mAb depletes tumour cells, Treg cells, MDSCs & TAMs that express this immunosuppressive enzyme, but not CTLs, NK cells or DCs, thus synergizing with PD-1 blockade: https://t.co/9tkKNuonGr. Also see: https://t.co/Xw0uq0AaS7 #ImmunoOnc
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Mashup Score: 0
Efficacious cancer vaccines can be made via the cryogenic silicification of tumour cells followed by the decoration of the silicified surface with pathogen-associated molecular patterns.
Source: Nature Biomedical EngineeringCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Preclinical study shows that cancer vaccines can be made via the cryogenic silicification of tumour cells, which preserves tumour antigens within nanoscopic layers of silica, followed by the decoration of the silicified surface with PAMPs: https://t.co/naiwzBqapr #ImmunoOnc
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Mashup Score: 1Closed-loop enhancement and neural decoding of cognitive control in humans - Nature Biomedical Engineering - 4 year(s) ago
Closed-loop electrical stimulation of the internal capsule of participants undergoing intracranial epilepsy monitoring improved the participants’ performance on a cognitive conflict task, and performance could be decoded from electrode activity.
Source: Nature Biomedical EngineeringCategories: Healthcare Professionals, Latest HeadlinesTweet-
RT @claytonsbingham: Closed-loop enhancement and neural decoding of cognitive control in humans https://t.co/Zhv960boQ5 "closed-loop direc…
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Mashup Score: 14Closed-loop enhancement and neural decoding of cognitive control in humans - Nature Biomedical Engineering - 4 year(s) ago
Closed-loop electrical stimulation of the internal capsule of participants undergoing intracranial epilepsy monitoring improved the participants’ performance on a cognitive conflict task, and performance could be decoded from electrode activity.
Source: Nature Biomedical EngineeringCategories: Latest Headlines, NeurologyTweet-
Original research: “Closed-loop enhancement and neural decoding of cognitive control in humans” by Alik S. Widge et al. Nature Biomedical Engineering https://t.co/ZmHrnWfCMp
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Mashup Score: 1Biomimetic cartilage-lubricating polymers regenerate cartilage in rats with early osteoarthritis - Nature Biomedical Engineering - 4 year(s) ago
Brush-like biopolymers mimicking the lubrication properties of natural cartilage-binding complexes in articular joints enhance cartilage regeneration in a rat model of early osteoarthritis.
Source: Nature Biomedical EngineeringCategories: Latest Headlines, RheumatologyTweet-
#ResearchHighlight | Restoring cartilage lubrication to heal post-traumatic #osteoarthritis #rheumatology #RegenerativeMedicine Read the original research from @natBME here https://t.co/ulAwfUstLE Read our #news story here https://t.co/wU6xU20q0Y
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“Scalable and modular wireless-network infrastructure for large-scale behavioral neuroscience” by Raza Qazi, et al. Nature Biomedical Engineering https://t.co/sN0T3kkaDh