Nelson et al. explore the abscopal effect, in which irradiation induces responses in adjacent non-irradiated sites, and discuss clinical and preclinical evidence in support of this phenomenon. With growing interest in combining radiotherapy with immunotherapy to elicit systemic anti-tumor responses, additional mechanistic and clinical validation will maximize its effectiveness.

We urgently need to identify new druggable targets for pediatric cancers. Coutinho et al.9 identified and validated XPO1 aberrant activity in patients with Wilms tumor (WT) and malignant rhabdoid tumor (MRT) using public databases and report an early proof-of-concept bench-to-bedside translation of XPO1 inhibition in pediatric WT and MRT.

We urgently need to identify new druggable targets for pediatric cancers. Coutinho et al.9 identified and validated XPO1 aberrant activity in patients with Wilms tumor (WT) and malignant rhabdoid tumor (MRT) using public databases and report an early proof-of-concept bench-to-bedside translation of XPO1 inhibition in pediatric WT and MRT.

We urgently need to identify new druggable targets for pediatric cancers. Coutinho et al.9 identified and validated XPO1 aberrant activity in patients with Wilms tumor (WT) and malignant rhabdoid tumor (MRT) using public databases and report an early proof-of-concept bench-to-bedside translation of XPO1 inhibition in pediatric WT and MRT.