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Mashup Score: 4Lack of ethnic diversity in single-cell transcriptomics hinders cell type detection and precision medicine inclusivity - 2 year(s) ago
Perhaps one of the most revolutionary next generation sequencing technologies is single-cell (SC) transcriptomics, which was recognized by Nature in 2013 as the method of the year. SC-technologies delve deep into genomics at the single-cell level, revealing previously restricted, valuable information on the identity of single cells, particularly highlighting their heterogeneity. Understanding the…
Source: MedCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 8Immune signatures predict development of autoimmune toxicity in patients with cancer treated with immune checkpoint inhibitors - 2 year(s) ago
Immune checkpoint inhibitors have revolutionized cancer treatment; however, they are associated with potentially life-threatening immune-related toxicities. In a prospective multi-center study of patients with melanoma and NSCLC, Nuñez et al. identified immune signatures occurring early after the start of treatment potentially predicting the onset of adverse events.
Source: MedCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 1Understanding CAR T cell-tumor interactions: Paving the way for successful clinical outcomes - 2 year(s) ago
Korell et al. review the state of CAR T cell therapy, including the requirements for activation, expansion, and persistence and the mechanisms used to kill tumor cells. Moreover, the review discusses known resistance mechanisms, remaining barriers to success in solid tumors, and future strategies to improve CAR T cell efficacy.
Source: MedCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 2Lack of ethnic diversity in single-cell transcriptomics hinders cell type detection and precision medicine inclusivity - 2 year(s) ago
Perhaps one of the most revolutionary next generation sequencing technologies is single-cell (SC) transcriptomics, which was recognized by Nature in 2013 as the method of the year. SC-technologies delve deep into genomics at the single-cell level, revealing previously restricted, valuable information on the identity of single cells, particularly highlighting their heterogeneity. Understanding the…
Source: MedCategories: General Medicine News, Latest HeadlinesTweet
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Mashup Score: 11Deep learning-enabled analysis of medical images identifies cardiac sphericity as an early marker of cardiomyopathy and related outcomes - 2 year(s) ago
Vukadinovic et al. study cardiac sphericity in a population of over 30,000 healthy adults using deep learning-enabled automated image segmentation. They show that sphericity predicts risk for cardiomyopathy in otherwise normal hearts independent of traditional clinical and imaging factors.
Source: MedCategories: Cardiologists, Latest HeadlinesTweet-
Measurement of LV sphericity index using convolutional neural network on cardiac MRI data in @uk_biobank finds in those w normal LV size & systolic function, ⬆️sphericity predicts incident CM,AF,HF sphericity has overlapping 🧬architecture w NICM,?Causal https://t.co/VtOSnRlHVJ https://t.co/VNKI96qKYU
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Mashup Score: 4Deep learning-enabled analysis of medical images identifies cardiac sphericity as an early marker of cardiomyopathy and related outcomes - 2 year(s) ago
Vukadinovic et al. study cardiac sphericity in a population of over 30,000 healthy adults using deep learning-enabled automated image segmentation. They show that sphericity predicts risk for cardiomyopathy in otherwise normal hearts independent of traditional clinical and imaging factors.
Source: MedCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 1
Nelson et al. explore the abscopal effect, in which irradiation induces responses in adjacent non-irradiated sites, and discuss clinical and preclinical evidence in support of this phenomenon. With growing interest in combining radiotherapy with immunotherapy to elicit systemic anti-tumor responses, additional mechanistic and clinical validation will maximize its effectiveness.
Source: MedCategories: Latest Headlines, Oncologists2Tweet
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Mashup Score: 0
Nelson et al. explore the abscopal effect, in which irradiation induces responses in adjacent non-irradiated sites, and discuss clinical and preclinical evidence in support of this phenomenon. With growing interest in combining radiotherapy with immunotherapy to elicit systemic anti-tumor responses, additional mechanistic and clinical validation will maximize its effectiveness.
Source: MedCategories: Hem/Oncs, Latest HeadlinesTweet
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Mashup Score: 10
Xing et al. estimated the global burden of cancers attributed to metabolic risks, including high body mass index and high fasting plasma glucose. Burden of metabolism-related neoplasms have increased significantly during the past decades. The findings are helpful for performing tailored screening for common cancers based on personalized features.
Source: MedCategories: Cardiologists, Latest HeadlinesTweet
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Mashup Score: 8
Nelson et al. explore the abscopal effect, in which irradiation induces responses in adjacent non-irradiated sites, and discuss clinical and preclinical evidence in support of this phenomenon. With growing interest in combining radiotherapy with immunotherapy to elicit systemic anti-tumor responses, additional mechanistic and clinical validation will maximize its effectiveness.
Source: MedCategories: Hem/Oncs, Latest HeadlinesTweet
"Lack of ethnic diversity in single-cell transcriptomics hinders cell type detection and precision medicine inclusivity" @MBRUniversity Mohammed Uddin Read more in @MedCellPress: https://t.co/j4pk5myj4w