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    The COVID-19 pandemic and its associated vaccine have highlighted vaccine hesitancy among healthcare workers (HCWs). Vaccine hesitancy among this group existed prior to the pandemic and particularly centered around influenza vaccination. Being a physician, having more advanced education, and previous vaccination habits are frequently associated with vaccine acceptance. The relationship between…

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    • Overall, doctors and other health professionals view covid-19 vaccines as highly beneficial, even taking into account rare harms, though they vary on how strongly and in what circumstances they’d recommend vaccination. https://t.co/KOckCHF90T 11/

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    It is widely accepted that nine hallmarks—including mitochondrial dysfunction, epigenetic alterations, and loss of proteostasis—exist that describe the cellular aging process. Adding to this, a well-described cell organelle in the metabolic context, namely, lipid droplets, also accumulates with increasing age, which can be regarded as a further aging-associated process. Independently of their…

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    • The Janus-Faced Role of Lipid Droplets in Aging: Insights from the Cellular Perspective https://t.co/u8PZgzIa7E #mdpibiomolecules via @Biomol_MDPI

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    Activating mutations in Kirsten rat sarcoma viral oncogene homologue (KRAS), in particular, a point mutation leading to a glycine-to-cysteine substitution at codon 12 (G12C), are among the most frequent genomic alterations in non-small cell lung cancer (NSCLC). Several agents targeting KRAS G12C have recently entered clinical development. Sotorasib, a first-in-class specific small molecule that…

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    • RT @CrozrX: Canadian Consensus Recommendations on the Management of KRASm G12C #NSCLC #KRAS 🫁 🔻 https://t.co/ZzZYl85C0e https://t.co/KISB…

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    Endometrial cancer (EC) is a major gynecological malignancy with rising morbidity and mortality worldwide. The aim of this study was to explore a safe and readily available sample and a sensitive and effective detection method and its biomarkers for early diagnosis of EC, which is critical for patient prognosis. This study designed a panel targeting variants for EC-related genes, assessed its…

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    • RT @ArturasDobilas: Very interesting and good results EndometrialCancer# ⁦@ESGO_society⁩ ⁦@nsgo_org⁩ ⁦@OncoAlert⁩ https://t.co/GtA10tmBpd

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    Non-alcoholic fatty liver disease (NAFLD) represents the most common chronic liver disease and it is considered the hepatic manifestation of metabolic syndrome (MetS). Diet represents the key element in NAFLD and MetS treatment, but some nutrients could play a role in their pathophysiology. Among these, fructose added to foods via high fructose corn syrup (HFCS) and sucrose might participate in…

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    • RT @ESpacetime: @JohnSpeakman4 @NeilFlochMD https://t.co/HFlISMCkSs This is part of the key. High fructose corn syrup changes leptin respo…

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    Brugada syndrome (BrS) is an inherited cardiac channelopathy with variable expressivity that can lead to sudden cardiac arrest (SCA). Studies worldwide suggest that BrS and Brugada pattern (BrP) have low prevalences in general. However, studies also note that BrS is most prevalent among certain Asian populations. Among the different global regions, the highest prevalence is believed to be in…

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    • Brugada syndrome within Asian populations: State-of-the-art review | #THIPubs @MihailChelu | @CardiogenMDPI https://t.co/jzYMyqVjuT

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    Since their discovery at the beginning of this millennium, glioma stem cells (GSCs) have sparked extensive research and an energetic scientific debate about their contribution to glioblastoma (GBM) initiation, progression, relapse, and resistance. Different molecular subtypes of GBM coexist within the same tumor, and they display differential sensitivity to chemotherapy. GSCs contribute to tumor…

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    • Review from @LeonidasPlatan1 and Frank Eckerdt, PhD, @LurieCancer discusses new insights in #glioma stem cell biology, including novel approaches that target GSCs in the age of immune-based strategies: https://t.co/ENu1wAeOuJ via @Cancers_MDPI #glioblastoma #btsm https://t.co/JC9JI8LjRP

  • Mashup Score: 3

    Since their discovery at the beginning of this millennium, glioma stem cells (GSCs) have sparked extensive research and an energetic scientific debate about their contribution to glioblastoma (GBM) initiation, progression, relapse, and resistance. Different molecular subtypes of GBM coexist within the same tumor, and they display differential sensitivity to chemotherapy. GSCs contribute to tumor…

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