• Mashup Score: 83

    This is an excellent overview at Stat on the current problems with machine learning in healthcare. It’s a very hot topic indeed, and has been for some time. There has especially been a flood of manuscripts during the pandemic, applying ML/AI techniques to all sorts of coronavirus-related issues. Som

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    • Machine learning papers based on COVID-19 lung scans are, almost without exception, worthless. Why is work of this low quality still getting constantly published, asks @Dereklowe https://t.co/NjsEFrsmik https://t.co/NjsEFrsmik

    • Shortcuts, "Frankenstein datasets," and lack of replication have plagued recent #AI studies, highlighted with #COVID19 medical imaging 2 very good summaries https://t.co/nqvdgbQ3Ve @Dereklowe https://t.co/Np8bU5VwzL @caseymross @statnews https://t.co/CEmJgFIioK

  • Mashup Score: 15
    A Word on Blog Topics - 3 year(s) ago

    I’ve had some queries that make me think that a brief meta-blog entry might be in order. I’m still fielding a lot of coronavirus queries, not all of which by any means make it up here to the blog. And at the same time, I’m also getting a lot of suggestions that are more in the classic mode: interest

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    • .@Dereklowe on why #Covid19 is going to be less a focus of his insightful blog going forward & why he's not playing whack-a-mole with all the objections vaccine-nervous people find not to get vaccinated. https://t.co/FZ9laN70hG

  • Mashup Score: 3
    Waiving IP - 3 year(s) ago

    The announcement by the Biden administration about waiving IP rights to the coronavirus vaccines obviously calls for some comment. Keep in mind that I have been doing research in the pharma industry for over 30 years now, so my viewpoint is obviously going to be affected by that, for better and for

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    • Then there is @Dereklowe from @ScienceMagazine who simply won't engage with any notion that patent rights are not absolute (under US law or international treaties), and anyone who suggests that flexibility might be warranted is a bomb-thrower of sorts. 8/ https://t.co/oOuKXikrEr

  • Mashup Score: 9

    There’s some really interesting CRISPR news out today, and it’s likely to be a forerunner of much more news to come. A research team has demonstrated what looks like robust, long-lasting effects in a primate model after one injection of the CRISPR enzymatic machinery. There have been plenty of roden

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    • Thank you @Dereklowe for this crisp summary of @VerveTx data "...reach into the body & fix such defects by a technology that (if you’d shown it to people a few decades ago) would have been hard to distinguish from magic. These are great times." Indeed! https://t.co/hIORMNXeG2

  • Mashup Score: 1
    Coronavirus Origins - 3 year(s) ago

    I’m going to regret writing about this, but it’s not a topic to be ignored. Where did the current coronavirus come from? If you ask that question, you get all sorts of answers from all sorts of people. Let me downgrade some of those right up front. To start at the far end of the fever scale, I do

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    • 'Coronavirus' Origins https://t.co/JD6IHN7HJz via @Dereklowe

  • Mashup Score: 2

    I really enjoyed reading this article in J. Med. Chem. on curcumin. (Update: here’s the take over at Practical Fragments). That’s a well-known natural product, found in large quantities in turmeric root (which is where most of the yellow color comes from). It has, over the years, been a hit in many,

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    • 'Curcumin Will Waste Your Time https://t.co/XluvaKwtHU via @Dereklowe https://t.co/sM8sOCpFNO

  • Mashup Score: 1

    There are a lot of slick ideas in molecular and chemical biology that depend on immobilizing proteins or small molecules onto solid supports. Consider affinity chromatography: if you can tether a “bait” onto some solid matrix, you can then flow all sorts of mixtures over it (gorp from freshly lysed

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    • 'Tie Me Proteins All Down, Sport https://t.co/2MFBVg4HsJ via @Dereklowe

  • Mashup Score: 46

    We have two pieces of news about the Gamaleya Institute’s “Sputnik-V” vaccine today. Neither of them are going to be enjoyable to go into. First off, many may have heard that the Brazilian regulatory authorities had a hearing yesterday to see if this vaccine would be approved for use there. They

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    • “Step up and act like responsible drug developers.” A great take on Sputnik from ⁦@Dereklowe⁩. https://t.co/kAI43NYsxW

    • .@Dereklowe on the Brazilian regulatory agency's decision to refuse to authorize Sputnik V for use there. The country needs vaccine. That it won't green light this one is noteworthy. https://t.co/sXtGSpPXWH

    • As always, excellent take on the Sputnik virus - replication competent Ad5 - controversy from @Dereklowe https://t.co/pOQ1PhDl8A

  • Mashup Score: 7

    Excellent news today: we have word of the most effective malaria vaccine yet discovered. A year-long trial in Burkina Faso has shown 77% efficacy, which is by far the record, and which opens the way to potentially relieving a nearly incalculable burden of disease and human suffering. This is a co

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    • Big vaccine news just out! @Dereklowe https://t.co/bjgHVrU1Bh

  • Mashup Score: 3

    So what’s the side effect that caused the J&J vaccine pause? Blood clotting – but not the usual kind. This appears to be the same (or very similar) to the problem seem with the Oxford/AstraZeneca vaccine in Europe, and both are very similar to a known syndrome called heparin-induced thrombocy

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    • 'Vaccine Side Effects Q and A https://t.co/FCf2IDPsYF As always @Dereklowe does a superb job disecting this syndrome and its implications.