• Mashup Score: 1

    Next Gen ACLY InhibitorInvestigational Stage ATP-citrate lyase (ACLY) is an enzyme strategically positioned at the intersection of nutrient catabolism and cholesterol and fatty acid biosynthesis. Esperion Therapeutics is leading the investigation of ACLY biology. While preclinical studies and Mendelian randomized trials support a causal role for ACLY in dyslipidemia and ASCVD, they also…

    Tweet Tweets with this article
    • Follow our science at https://t.co/E4bwYhx4sR #CVD #LDL #patientsfirst https://t.co/YvlQyrhrVk

  • Mashup Score: 0

    Importance Additional treatment options are needed for patients who do not achieve sufficient reduction in low-density lipoprotein cholesterol (LDL-C) level with available lipid-lowering therapies. Objective To assess the efficacy of bempedoic acid vs placebo in patients at high cardiovascular risk receiving maximally tolerated lipid-lowering therapy. Design, Setting, and…

    Tweet Tweets with this article