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Mashup Score: 0Metformin and simvastatin exert additive antitumour effects in glioblastoma via senescence-state: clinical and translational evidence - 1 year(s) ago
Altogether, metformin and simvastatin reduce aggressiveness features in glioblastomas, being this effect significantly more effective (in vitro/in vivo) when both drugs are combined, offering a clinically relevant opportunity that should be tested for their use in humans.
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet
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Mashup Score: 1
Diverse cellular and molecular biomarkers for LC have been proposed. Validation of candidate biomarkers in independent samples should be prioritized. Modest reported performance (particularly in larger studies) suggests LC may encompass many distinct aetiologies, which should be explored e.g., by stratifying by symptom clusters and/or sex.
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
RT @LongCOVIDPhysio: @eBioMedicine Cellular and molecular biomarkers of #LongCOVID: a scoping review https://t.co/gWVGFN8Ejs
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Mashup Score: 0SARS-CoV-2 variant transition dynamics are associated with vaccination rates, number of co-circulating variants, and convalescent immunity - 1 year(s) ago
These results suggest the behavior of an emergent variant may be sensitive to the immunologic and demographic context of its location. Additionally, this work represents the most comprehensive characterization of variant transitions globally to date.
Source: EBioMedicineCategories: Critical Care, Latest HeadlinesTweet-
#SARS-CoV-2 variant #transition dynamics are associated with #vaccination rates, number of co-circulating #variants, and convalescent #immunity https://t.co/Xqp0eet6Wq https://t.co/PKRAPcMf46
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Mashup Score: 0Prognostic evaluation of polygenic risk score underlying pan-cancer analysis: evidence from two large-scale cohorts - 1 year(s) ago
Our findings indicate that the risk-specific PRS might not be a clinically useful tool in cancer prognosis prediction and further studies focusing on the development of polygenic prognostic score are warranted.
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Editor pick from Mar issue J Xin & coll present evidence from 2 large cohorts to evaluate the prognostic value of polygenic risk score underlying pan-cancer analysis Read https://t.co/OuBpm4w3wa https://t.co/eZkGS61bAa
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Mashup Score: 0Prognostic evaluation of polygenic risk score underlying pan-cancer analysis: evidence from two large-scale cohorts - 1 year(s) ago
Our findings indicate that the risk-specific PRS might not be a clinically useful tool in cancer prognosis prediction and further studies focusing on the development of polygenic prognostic score are warranted.
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Editor pick from Mar issue J Xin & coll present evidence from 2 large cohorts to evaluate the prognostic value of polygenic risk score underlying pan-cancer analysis Read https://t.co/OuBpm4wBlI https://t.co/WI9UXpJI1D
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Mashup Score: 0
Circadian rhythms regulate various processes in the human body, including drug metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the individual patient, such that the treatment efficacy is maximized, and adverse effects are minimized. It has been explored in different cancers with varying conclusions. Glioblastoma multiforme (GBM) is the most aggressive type of…
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Editor pick of Mar issue M Petkovic & coll review recent advances in chronotherapy regimens for treatment of #Glioblastoma treatments w/ drugs of circadian phase specific activity new approaches targeting elements of the circadian clock. Read https://t.co/vqpUHGVeKe https://t.co/jApld6k4ku
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Mashup Score: 1
Circadian rhythms regulate various processes in the human body, including drug metabolism. Chronotherapy optimizes treatment timing based on the circadian rhythm of the individual patient, such that the treatment efficacy is maximized, and adverse effects are minimized. It has been explored in different cancers with varying conclusions. Glioblastoma multiforme (GBM) is the most aggressive type of…
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Editor pick of Mar issue M Petkovic & coll review recent advances in chronotherapy regimens for treatment of #Glioblastoma treatments w/ drugs of circadian phase specific activity new approaches targeting elements of the circadian clock. Read https://t.co/vqpUHGVMzM https://t.co/uJhUkLq0or
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Mashup Score: 1Algorithmic encoding of protected characteristics in chest X-ray disease detection models - 1 year(s) ago
Subgroup analysis is key for identifying performance disparities of AI models, but statistical differences across subgroups need to be taken into account when analyzing potential biases in disease detection. The proposed methodology provides a comprehensive framework for subgroup analysis enabling further research into the underlying causes of disparities.
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Editor pick from March issue @GlockerBen & coll shed some light on how dataset biases manifest in predictive models by exploring methodology for subgroup analysis in image-based disease detection models. Read https://t.co/24UbBYmPna #bias #disparities #fairness https://t.co/BU32uJALrI
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Mashup Score: 3Incorporating variant frequencies data into short-term forecasting for COVID-19 cases and deaths in the USA: a deep learning approach - 1 year(s) ago
Based on our findings, the proposed forecasting framework improves upon the available state-of-the-art forecasting tools currently used to support public health decision making with respect to COVID-19 risk.
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Editor pick from March issue @TexasDownUnder & coll present a novel multi-stage DL model to forecast the nb of #COVID19 cases & deaths for each US state at a weekly level for a forecast horizon of 1–4 weeks Read https://t.co/fyagNzX5fE
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Mashup Score: 0Incorporating variant frequencies data into short-term forecasting for COVID-19 cases and deaths in the USA: a deep learning approach - 1 year(s) ago
Based on our findings, the proposed forecasting framework improves upon the available state-of-the-art forecasting tools currently used to support public health decision making with respect to COVID-19 risk.
Source: EBioMedicineCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
Editor pick from March issue @TexasDownUnder & coll present a novel multi-stage DL model to forecast the nb of #COVID19 cases & deaths for each US state at a weekly level for a forecast horizon of 1–4 weeks Read https://t.co/fyagNzWxq6 https://t.co/1gJNxZ9TEC
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Feature of Apr issue @antoniocafufa&coll @OncMet27 Evaluated the effects of metformin & statins on key functional/molecular/signalling parameters in glioblastoma pts &cells ➡️metformin & simvastatin reduce aggressiveness features in glioblastomas Read https://t.co/4DkYGYmqw3 https://t.co/twHFuE67lO