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Mashup Score: 2
Background: The pioneer transcription factor (TF) GATA4 (GATA Binding Protein 4) is expressed in multiple cardiovascular lineages and is essential for heart development. GATA4 lineage-specific occupa
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet
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Mashup Score: 1Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms - 1 year(s) ago
Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase sub
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Katsuki & colleagues demonstrate that circulating #PCSK9 promotes #macrophage activation and experimental vein graft lesion development via #LDL receptor-independent mechanisms. Learn more at https://t.co/UPrDHUBoAf @aikawa_masanori https://t.co/ArV0xD2w7l
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Mashup Score: 0
Background: Phenotypic transition of vascular smooth muscle cells (VSMCs) accounts for the pathogenesis of a variety of vascular diseases during the early stage. Recent studies indicate the metabolic
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
2/5 Wei Kong et al from Peking University published the study PHB2 Maintains the Contractile Phenotype of VSMCs by Counteracting PKM2 Splicing (https://t.co/R7I5x0Ren1)
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Mashup Score: 2
Background: The arterial pole of the heart is a hotspot for life-threatening forms of congenital heart defects (CHDs). Development of this cardiac region occurs by addition of Second Heart Field (SHF
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
3/5 @LabRochais & Robert Kelly et al found PPARg and NOTCH Regulate Regional Identity in the Murine Cardiac Outflow Tract https://t.co/vmSOUHXHPs
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Mashup Score: 0
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
4/5 Maomao Zhang et al at Harbin Medical University found Histone Lactylation Boosts Reparative Gene Activation Post Myocardial Infarction https://t.co/jwwmTp4jR9
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Mashup Score: 0Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms - 1 year(s) ago
Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinical problem with limited therapeutic options. PCSK9 (proprotein convertase sub
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
5/5 @aikawa_masanori et al at @BrighamWomens show PCSK9 Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms https://t.co/eAsstub4V6
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Mashup Score: 2
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Wang & colleagues demonstrate that the #epigenetic modification histone lactylation facilitates #transcription of reparative genes, thus favoring the establishment of #immune homeostasis and improving cardiac function post-#MI. Learn more at https://t.co/lfaTPrOLCu https://t.co/jfb8K2GIYi
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Mashup Score: 3Sex Differences and Similarities in Valvular Heart Disease - 1 year(s) ago
As populations age worldwide, the burden of valvular heart disease has grown exponentially, and so has the proportion of affected women. Although rheumatic valve disease is declining in high-income c
Source: Circulation ResearchCategories: Cardiologists, Latest HeadlinesTweet-
5/ Women have⬆️mortality than men during surgical aortic or mitral interventions 🚩Older age 🚩More frail 🚩More comorbidities ⬇️rates of aortic valve replacement in women than men Among those referred for AVR, ⬆️TAVR vs SAVR among women than men https://t.co/qJ95j7fsbr https://t.co/MNUxTdi9at
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Mashup Score: 2
Remy Martins-Gonçalves, Mariana M. Campos, Lohanna Palhinha, Isaclaudia G. Azevedo-Quintanilha, Mayara Abud Mendes, Jairo Ramos Temerozo, Júlia Toledo-Mendes, Paulo H. Rosado-de-Castro, Fernando A. Bozza, Rosana Souza Rodrigues, Eugenio D. Hottz and Patricia T. Bozza Remy Martins-GonçalvesRemy Martins-Gonçalves https://orcid.org/0000-0002-1010-6162 Laboratory of Immunopharmacology, Oswaldo…
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Martins-Gonçalves et al found that #platelet activation & hyperreactivity can persist in #COVID19 survivors after hospital discharge. Learn more about post-COVID-19 #hypercoagulability at https://t.co/ODhK1ktE4V @juliatoledo_ https://t.co/Oru7yimZve
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Mashup Score: 2
Background: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 (CCM3). CCMs affect ≈1 out
Source: Circulation ResearchCategories: Cardiology News and Journals, Latest HeadlinesTweet-
Lai et al found #neuroinflammatory mechanisms that influence critical aspects of the #CCM pathology, including lesion genesis, brain bleedings & #thrombosis that cause disabilities in patients. Learn more at https://t.co/yMQYAD2mHY @MiguelALopezRa1 @marcoorecchioni https://t.co/C3tLiTA3bd
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Zhou & colleagues demonstrate that #GATA4-#ETS1 interaction in #endocardium regulates endocardial gene expression and #heart development. Learn more at https://t.co/VFZbYZ0ygq @Dr.LincaiYe @AbinHe @FengXiao1988 https://t.co/0g3wAnNCdp