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Mashup Score: 2
Primary liver cancer (PLC) includes hepatocellular carcinoma and intrahepatic cholangiocarcinoma and is the sixth most common cancer worldwide with poor prognosis. PLC is characterized by an abundant stromal reaction in which cancer-associated fibroblasts (CAFs) are one of the major stromal components. Solid evidence has demonstrated the crucial role of CAFs in tumor progression, and CAF…
Categories: Gastroenterology, Latest HeadlinesTweet
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Mashup Score: 0Hepatocyte Smoothened Activity Controls Susceptibility to Insulin Resistance and Nonalcoholic Fatty Liver Disease - 2 year(s) ago
Nonalcoholic steatohepatitis (NASH), a leading cause of cirrhosis, strongly associates with the metabolic syndrome, an insulin-resistant proinflammatory state that disrupts energy balance and promotes progressive liver degeneration. We aimed to define the role of Smoothened (Smo), an obligatory component of the Hedgehog signaling pathway, in controlling hepatocyte metabolic homeostasis and,…
Categories: Gastroenterology, Latest HeadlinesTweet-
Hepatocytes require Smo to protect adult livers from metabolic stress that causes #NAFLD, pre-diabetes and aging. Read the article here ➡️ https://t.co/tbwbotNQpC https://t.co/0hh3Kwq86u
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Mashup Score: 2H3K27me3 Demethylases Maintain the Transcriptional and Epigenomic Landscape of the Intestinal Epithelium - 2 year(s) ago
Although trimethylation of histone H3 lysine 27 (H3K27me3) by polycomb repressive complex 2 is required for intestinal function, the role of the antagonistic process—H3K27me3 demethylation—in the intestine remains unknown. The aim of this study was to determine the contribution of H3K27me3 demethylases to intestinal homeostasis.
Categories: Gastroenterology, Latest HeadlinesTweet-
Study finds H3K27me3 demethylases maintain the transcriptional and epigenomic landscape of the intestinal epithelium. Check out the full article here: https://t.co/eKhwZhl42o https://t.co/alAyk4r6OZ
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Mashup Score: 0Novel Fat Taste Receptor Agonists Curtail Progressive Weight Gain in Obese Male Mice - 2 year(s) ago
The spontaneous preference for dietary lipids is principally regulated by 2 lingual fat taste receptors, CD36 and GPR120. Obese animals and most of human subjects exhibit low orosensory perception of dietary fat because of malfunctioning of these taste receptors. Our aim was to target the 2 fat taste receptors by newly synthesized high affinity fatty acid agonists to decrease fat-rich food intake…
Categories: Gastroenterology, Latest HeadlinesTweet-
Study finds novel fat taste receptor agonists curtail progressive weight gain in obese male mice. Read the full article here: https://t.co/p3zEcds1IK @KhanNai31913922 https://t.co/EnyD9B7l0Z
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Mashup Score: 2
The intestinal epithelium intrinsically renews itself ex vivo via the proliferation of Lgr5+ intestinal stem cells, which is sustained by the establishment of an epithelial stem cell niche. Differentiated Paneth cells are the main source of epithelial-derived niche factor supplies and produce Wnt3 as an essential factor in supporting Lgr5+ stem cell activity in the absence of redundant…
Categories: Gastroenterology, Latest HeadlinesTweet-
HNF4A regulates WNT3 production from Paneth cells with an impact on intestinal crypt homeostasis. Click the link to learn more: https://t.co/SwZAZHYc15 @Labo_FBoudreau https://t.co/tGR9gt6oOD
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Mashup Score: 0Axin1 Protects Colon Carcinogenesis by an Immune-Mediated Effect - 2 year(s) ago
Axin1 is a negative regulator of wingless-type MMTV integration site family, member 1 (Wnt)/β-catenin signaling with tumor-suppressor function. The Wnt pathway has a critical role in the intestine, both during homeostasis and cancer, but the role of Axin1 remains elusive.
Categories: Gastroenterology, Latest HeadlinesTweet-
Axin1 protects #colon carcinogenesis by an immune-mediated effect and not by Wnt pathway inhibition. Click here to learn more ➡️ https://t.co/SjXrjYb8w1 https://t.co/AcWMqhTDtF
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Mashup Score: 0Loss of SQSTM1/p62 Induces Obesity and Exacerbates Alcohol-Induced Liver Injury in Aged Mice - 2 year(s) ago
Alcohol-associated liver disease (ALD) is a worldwide health problem, of which the effective treatment is still lacking. Both detrimental and protective roles of adipose tissue have been implicated in ALD. Although alcohol increases adipose tissue lipolysis to promote alcohol-induced liver injury, alcohol also activates brown adipose tissue (BAT) thermogenesis as an adaptive response in…
Categories: Gastroenterology, Latest HeadlinesTweet-
Article in Press finds loss of SQSTM1/p62 induces obesity and exacerbates alcohol-induced liver injury in aged mice. Read the full article at https://t.co/sGg3ucyAIv https://t.co/NvPGTkdkvA
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Mashup Score: 0Targeting Notch1-YAP Circuit Reprograms Macrophage Polarization and Alleviates Acute Liver Injury in Mice - 2 year(s) ago
Hepatic immune system disorder plays a critical role in the pathogenesis of acute liver injury. The intrinsic signaling mechanisms responsible for dampening excessive activation of liver macrophages are not completely understood. The Notch and Hippo-YAP signaling pathways have been implicated in immune homeostasis. In this study, we investigated the interactive cell signaling networks of…
Categories: Gastroenterology, Latest HeadlinesTweet-
Article in Press finds targeting notch1-YAP circuit reprograms macrophage polarization and alleviates acute liver injury in mice. Read the full article at https://t.co/HiDjANTOFe https://t.co/AwzzAnc3ae
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Mashup Score: 1Calcium Channel α2δ1 is Essential for Pancreatic Tumor-Initiating Cells through Sequential Phosphorylation of PKM2 - 2 year(s) ago
Tumor-initiating cells (TICs) drive pancreatic cancer tumorigenesis, therapeutic resistance, and metastasis. However, TICs are highly plastic and heterogenous, which impede the robust identification and targeted therapy of such a population. The aim of this study is to identify the surface marker and therapeutic target for pancreatic TICs.
Categories: Gastroenterology, Latest HeadlinesTweet-
Calcium channel α2δ1 was identified as a more robust marker and therapeutic target for pancreatic cancer stem cells. Learn more at https://t.co/LhW9t3Ubb9 @biologyZhang9 https://t.co/t3b65QN7YR
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Mashup Score: 0DCLK1 Suppresses Tumor-Specific Cytotoxic T Lymphocyte Function Through Recruitment of MDSCs via the CXCL1-CXCR2 Axis - 2 year(s) ago
Gastrointestinal cancer stem cell marker doublecortin-like kinase (DCLK1) is strongly associated with poor outcomes in colorectal cancer (CRC). Although DCLK1’s regulatory effect on the tumor immune microenvironment has been hypothesized, its mode of action has not been shown previously in vivo, which hampers the potential intervention based on this molecule for clinical practice.
Categories: Gastroenterology, Latest HeadlinesTweet-
Study finds that previously recognized CRC driver DCLK1 can assist the immune escape of tumor cells. View the full article at https://t.co/JASAPYdHXm https://t.co/kimko6Ilxk
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Review summarizes the recent advances in the understanding of CAF diversity and pivotal roles in primary #liver cancer. Read the full article here ➡️ https://t.co/W72NQtCqYk @kw_terence https://t.co/sSumHzAzy9