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Mashup Score: 3A novel network approach to multiscale biological regulation - 1 year(s) ago
Modeling systems at multiple interacting scales is probably the most relevant task for pursuing a physically motivated explanation of biological regulation. In a new study, Smart and Zilman develop a convincing, albeit preliminary, model of the interplay between the cell microscale and the macroscopic tissue organization in biological systems.
Source: Cell SystemsCategories: Healthcare Professionals, Latest HeadlinesTweet
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Mashup Score: 6
“Good code” is often regarded as a nebulous, impractical ideal. Common best practices toward improving code quality can be inaccessible to those without a rigorous computer science or software engineering background, contributing to a gap between advancing scientific research and FAIR practices. We seek to equip researchers with the necessary background and context to tackle the challenge of…
Source: Cell SystemsCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @moorejh: The in silico lab: Improving academic code using lessons from biology https://t.co/vv1CzdPFyG #coding #bioinformatics
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Mashup Score: 0Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells - 1 year(s) ago
This study shows emergence of oscillations in HIF-1α transcriptional activity in dense, hypoxic cancer cell populations. Lactate, a byproduct of HIF-1α-induced glycolysis, acts as a quorum-sensing signal driving HIF-1α oscillations, allowing cells to escape the cell-cycle arrest. HIF-1α oscillations decrease expression of tumor suppressor genes in many cancers.
Source: Cell SystemsCategories: Hem/Oncs, Latest HeadlinesTweet-
Lactate-dependent chaperone-mediated autophagy induces oscillatory HIF-1α activity promoting proliferation of hypoxic cells: Cell Systems https://t.co/BLgO5CAPZE
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Mashup Score: 0Somatic XIST activation and features of X chromosome inactivation in male human cancers - 1 year(s) ago
XIST is somatically expressed in a subset of male cancers and appears functionally active, indicating that a normally female-specific, developmentally restricted program for chromosome-wide dosage compensation can be somatically accessed in some male cancers.
Source: Cell SystemsCategories: General Medicine News, Latest HeadlinesTweet-
Some XY cancers inactivate the X chromosome; an example of a sex specific difference associated with these cancers. @srviswanathan Read more in @CellSystemsCP: https://t.co/oC3YXj4EPh
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Mashup Score: 2Somatic XIST activation and features of X chromosome inactivation in male human cancers - 1 year(s) ago
XIST is somatically expressed in a subset of male cancers and appears functionally active, indicating that a normally female-specific, developmentally restricted program for chromosome-wide dosage compensation can be somatically accessed in some male cancers.
Source: Cell SystemsCategories: General Medicine News, Latest HeadlinesTweet-
Some XY cancers inactivate the X chromosome; an example of a sex specific difference associated with these cancers. @srviswanathan Read more in @CellSystemsCP: https://t.co/oC3YXj46ZJ
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Mashup Score: 1Alignment of single-cell trajectories by tuMap enables high-resolution quantitative comparison of cancer samples - 2 year(s) ago
Single-cell technologies provide unprecedentedly large amounts of data, of which only a small fraction is utilized. Trajectory inference methodologies leverage the detailed information to gain temporal resolution in process characterization. Yet, in cancer, patient heterogeneity prevents quantitative comparison of the processes occurring in different patients, an essential step for clinical…
Source: Cell SystemsCategories: General Medicine News, Latest HeadlinesTweet-
Read a recent paper from @CellSystemsCP and learn what the author @shenorr has to say about their work https://t.co/pV9If8llK8 https://t.co/Sa4Civz7ts
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Mashup Score: 4Human plasma IgG1 repertoires are simple, unique, and dynamic - 2 year(s) ago
The human body produces immunoglobulins (Igs) to help combat pathogens. The number of distinct IgG molecules our body can produce exceeds several billions. In contrast to this near-infinite theoretical number, we reveal here, as monitored directly by LC-MS, that only a few dozen distinct clones dominate in abundance the total spectrum of plasma IgG1s of both healthy and diseased donors. Our data…
Source: Cell SystemsCategories: General Medicine News, Latest HeadlinesTweet-
Human plasma IgG1 repertoires are simple, unique, and dynamic - read the full article by Albert J.R. Heck @hecklab & others in @CellSystemsCP #AAI2022 https://t.co/J0ac6PqtzZ
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Mashup Score: 1Tissue schematics map the specialization of immune tissue motifs and their appropriation by tumors - 2 year(s) ago
We present Tissue Schematics, a computational and conceptual framework for using high-parameter imaging data to map how tissues are formed by the assembly of cellular neighborhoods into tissue motifs. Applying our framework to human lymphoid tissues and the colorectal cancer immune-tumor microenvironment suggests mechanistic insights into the specific biology of these tissues, as well as general…
Source: Cell SystemsCategories: General Medicine News, Latest HeadlinesTweet-
Tissue schematics map the specialization of immune tissue motifs and their appropriation by tumors - full article by @GarryPNolan et al. published in @CellSystemsCP #AAI2022 https://t.co/hBnxZzv4Kk
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Mashup Score: 2The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner - 2 year(s) ago
Hamelin et al. investigated the global mutation landscape of SARS-CoV-2 by interrogating 330,246 SARS-CoV-2 sequences from GISAID. The dominant C→U mutation type was found to diversify the repertoire of experimentally validated SARS-CoV-2 CD8+ T cell epitopes in an HLA-supertype-dependent manner. Notably, the prevalent removal of proline was predicted to preferentially abrogate epitopes presented…
Source: Cell SystemsCategories: General Medicine News, Latest HeadlinesTweet-
The mutational landscape of SARS-CoV-2 variants diversifies T cell targets in an HLA-supertype-dependent manner - @EtienneCaron15 et al. @CellSystemsCP #AAI2022 https://t.co/ObR60OTCac
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Mashup Score: 0Evolutionary velocity with protein language models predicts evolutionary dynamics of diverse proteins - 2 year(s) ago
Evolutionary patterns learned by a single protein language model can construct a “vector field” of protein evolution termed “evolutionary velocity” that predicts evolutionary dynamics across diverse proteins, from viral proteins evolving over years to highly conserved proteins evolving over geologic eons.
Source: Cell SystemsCategories: Future of Medicine, Latest HeadlinesTweet-
Evolutionary velocity uses local predictions of protein mutational fitness from a deep learning model to recover complex evolutionary landscapes. #NBThighlight https://t.co/bhZSoxoBbr
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RT @CellSystemsCP: Preview: Emergent properties of collective gene-expression patterns in multicellular systems. https://t.co/8ChqgJX5zc