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Mashup Score: 0
Cetuximab is approved for the treatment of metastatic colorectal cancer (mCRC) with RAS wild-type. Nevertheless, the prognosis remains poor and the effectiveness of cetuximab is limited in KRAS mutant mCRC. Recently, emerging evidence has shown that ferroptosis, a newly discovered form of nonapoptotic cell death, is closely related to KRAS mutant cells. Here, we further investigated whether…
Source: Cell Death & DiseaseCategories: Hem/Onc News and Journals, Latest HeadlinesTweet
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Mashup Score: 1
Listeria monocytogenes (LM) infection induces pyroptosis, a form of regulated necrosis, in host macrophages via inflammasome activation. Here, we examined the role of Mint3 in macrophages, which promotes glycolysis via hypoxia-inducible factor-1 activation, during the initiation of pyroptosis following LM infection. Our results showed that Mint3-deficient mice were more resistant to lethal…
Source: Cell Death & DiseaseCategories: Infectious Disease, Latest HeadlinesTweet-
Scientists from @UTokyo_News_en examined the role of Mint3 in #macrophages, which promoted glycolysis via hypoxia-inducible factor-1 activation, during the initiation of pyroptosis following Listeria monocytogenes #infection. https://t.co/oIYFi5Pfgz https://t.co/vemyaKdH1G
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Mashup Score: 1FGFR3△7–9 promotes tumor progression via the phosphorylation and destabilization of ten-eleven translocation-2 in human hepatocellular carcinoma - 3 year(s) ago
Overexpression of fibroblast growth factor receptor 3 (FGFR3) correlates with more severe clinical features of hepatocellular carcinoma (HCC). Our previous study has shown that FGFR3∆7–9, a novel splicing mutation of FGFR3, contributes significantly to HCC malignant character, but the epigenetic mechanism is still elusive. In this study, through mass spectrometry and co-immunoprecipitation…
Source: Cell Death & DiseaseCategories: Future of Medicine, Latest HeadlinesTweet-
FGFR3△7–9 promotes tumor progression via the phosphorylation and destabilization of ten-eleven translocation-2 in human hepatocellular carcinoma https://t.co/pvOEYYJ93J Best, -NK & @NEBiolabs #EpiMark #5hmC https://t.co/CFXi6hRrSD
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Mashup Score: 1FAT10 protects against ischemia-induced ventricular arrhythmia by decreasing Nedd4-2/Nav1.5 complex formation - 3 year(s) ago
The human leukocyte antigen F-associated transcript 10 (FAT10) is a member of the small ubiquitin-like protein family that binds to its target proteins and subjects them to degradation by the ubiquitin–proteasome system (UPS). In the heart, FAT10 plays a cardioprotective role and affects predisposition to cardiac arrhythmias after myocardial ischemia (MI). However, whether and how FAT10…
Source: Cell Death & DiseaseCategories: Cardiology News and Journals, Latest HeadlinesTweet-
FAT10 Protects Against Ischemia-Induced Ventricular Arrhythmia by Decreasing Nedd4-2/Nav1.5 Complex Formation | #THIPubs @Texas_Heart @nresearchnews #CellDeathDis Learn more: https://t.co/BP6DMKR621 https://t.co/vztM6991g1
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Mashup Score: 0Preclinical evaluation of a regimen combining chidamide and ABT-199 in acute myeloid leukemia - 4 year(s) ago
Acute myeloid leukemia (AML) is a heterogeneous myeloid neoplasm with poor clinical outcome, despite the great progress in treatment in recent years. The selective Bcl-2 inhibitor venetoclax (ABT-199) in combination therapy has been approved for the treatment of newly diagnosed AML patients who are ineligible for intensive chemotherapy, but resistance can be acquired through the upregulation of…
Source: Cell Death & DiseaseCategories: Hem/Onc News and Journals, Latest HeadlinesTweet-
Chen, K., Yang, Q., Zha, J. et al. Preclinical evaluation of a regimen combining chidamide and ABT-199 in acute myeloid leukemia. Cell Death Dis 11, 778 (2020). https://t.co/0ykiD1aeIX
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Mashup Score: 1EB virus-induced ATR activation accelerates nasopharyngeal carcinoma growth via M2-type macrophages polarization - 4 year(s) ago
Chronic inflammation induced by persistent viruses infection plays an essential role in tumor progression, which influenced on the interaction between the tumor cells and the tumor microenvironment. Our earlier study showed that ATR, a key kinase participant in single-stranded DNA damage response (DDR), was obviously activated by Epstein–Barr virus (EBV) in nasopharyngeal carcinoma (NPC)….
Source: Cell Death & DiseaseCategories: Infectious Disease, Latest HeadlinesTweet-
Epstein–Barr virus infection could activate the ATR pathway to accelerate the transition of tumor associated #macrophages to M2, according to @SiChuanUniv researchers. 🔓 Read it @cddpress: https://t.co/kY4Ansx0sP https://t.co/ckfcjW4hP0
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Mashup Score: 15
BH3-mimetics are a new class of anti-cancer drugs that inhibit anti-apoptotic Bcl-2 proteins. In doing so, BH3-mimetics sensitise to cell death. Venetoclax is a potent, BCL-2 selective BH3-mimetic that is clinically approved for use in chronic lymphocytic leukaemia. Venetoclax has also been shown to inhibit mitochondrial metabolism, this is consistent with a proposed role for BCL-2 in metabolic…
Source: Cell Death & DiseaseCategories: Hem/Oncs, Latest HeadlinesTweet-
RT @DrTonyLetai: Some badly needed clarity from Alba Roca-Portoles and Stephen Tait. https://t.co/1MMw24W3Y2 Venetoclax can have metaboli…
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Mashup Score: 1
BH3-mimetics are a new class of anti-cancer drugs that inhibit anti-apoptotic Bcl-2 proteins. In doing so, BH3-mimetics sensitise to cell death. Venetoclax is a potent, BCL-2 selective BH3-mimetic that is clinically approved for use in chronic lymphocytic leukaemia. Venetoclax has also been shown to inhibit mitochondrial metabolism, this is consistent with a proposed role for BCL-2 in metabolic…
Source: Cell Death & DiseaseCategories: Hem/Oncs, Latest HeadlinesTweet-
Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition | Cell Death & Disease https://t.co/UiiQT6EVwy
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Mashup Score: 1The inhibition of IL-2/IL-2R gives rise to CD8+ T cell and lymphocyte decrease through JAK1-STAT5 in critical patients with COVID-19 pneumonia - 4 year(s) ago
Although most patients with COVID-19 pneumonia have a good prognosis, some patients develop to severe or critical illness, and the mortality of critical cases is up to 61.5%. However, specific molecular information about immune response in critical patients with COVID-19 is poorly understood. A total of 54 patients were enrolled and divided into three groups, among which 34 were common, 14 were…
Source: Cell Death & DiseaseCategories: Infectious Disease, Latest HeadlinesTweet-
Research published in @cddpress found that the decrease of CD8+ T cells in critical patients with #COVID-19 pneumonia may be related to the IL-2 signaling pathway. ✔️ Open access: https://t.co/AUvbQ0yt44 https://t.co/UQe73yeOye
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Cetuximab can promote RSL3-induced ferroptosis by suppressing the Nrf2/HO-1 signalling pathway in KRAS-mutant CRC: https://t.co/ShTSufBlOo #CRCSM. For more on ferroptosis in cancer, see: https://t.co/2B41c6TA8t