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Mashup Score: 10Muscle loss phenotype in COPD is associated with adverse outcomes in the UK Biobank - BMC Pulmonary Medicine - 4 day(s) ago
Background Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disorder with systemic consequences that can cause a muscle loss phenotype (MLP), which is characterized by the loss of muscle mass, muscle strength, or loss of both muscle and fat mass. There are limited data comparing the individual traits of MLP with clinical outcomes in a large unbiased cohort of COPD patients. Our aim was to determine the proportion of patients who met criteria for MLP in an unbiased sample of COPD patients at the population-level. We also determined if specific MLP features were associated with all-cause and COPD-related mortality. Methods A retrospective population-based cohort analysis of the UK Biobank was performed. COPD was defined by a FEV1/FVC ratio < 0.7, physician established diagnosis of COPD, or those with a COPD-related hospitalization before baseline assessment. MLP included one or more of the following: 1) Low fat-free mass index (FFMI) on bioelectric impedance analysi
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Mashup Score: 2Primary endobronchial melanoma: a case report and clinical management indications - BMC Pulmonary Medicine - 2 month(s) ago
Background While cutaneous melanomas are well-documented, primary melanoma of the lung (PMML), particularly with endobronchial origin, remains rare and poorly characterized. This case report addresses gaps in understanding by presenting a comprehensive case of a 71-year-old male with primary endobronchial melanoma and conducting a systematic review of PMML cases. Case Presentation The patient, a former smoker, presented with dyspnea, cough, and hemoptysis. Imaging revealed left lung atelectasis and a suspicious nodule. Bronchoscopy identified an endobronchial mass, subsequently treated with argon plasma coagulation and resection. Biopsy confirmed melanoma. Extensive examinations ruled out a primary skin lesion. Despite initial treatment, recurrence led to pneumonectomy. Histopathology confirmed melanoma. The patient received treatment with pembrolizumab and ipilimumab, but with poor clinical benefit. Conclusions Primary endobronchial melanoma is a rare entity, comprising 0.01% of lung
Source: bmcpulmmed.biomedcentral.comCategories: General Medicine News, General HCPsTweet-
A Case Report published in #BMCPulmMed presents a case of a 71-year-old male with primary endobronchial melanoma. https://t.co/zTM3BgY5wI
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Mashup Score: 0
Background Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is established as the preferred method of mediastinal lymph node (LN) staging in non-small cell lung cancer (NSCLC). Selective (targeted) LN sampling is most commonly performed however studies in early stage NSCLC and locally advanced NSCLC confirm systematic EBUS-TBNA evaluation improves accuracy of mediastinal staging. This study aims to establish the rate of detection of positron emission tomography (PET)-occult LN metastases following systematic LN staging by EBUS-TBNA, and to determine the utility of systematic mediastinal staging for accurate delineation of radiation treatment fields in patients with locally advanced NSCLC. Methods Consecutive patients undergoing EBUS-TBNA for diagnosis/staging of locally advanced NSCLC will be enrolled in this international multi-centre single arm study. Systematic mediastinal LN evaluation will be performed, with all LN exceeding 6 mm to be sampled by TBNA.
Source: bmcpulmmed.biomedcentral.comCategories: General Medicine News, Hem/OncsTweet-
Here, you can learn more about the study design as we wait for publication of the study results. https://t.co/MbRsTk9DrC https://t.co/NAciyLslNP
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Mashup Score: 2
Background The fracture risk of patients with chronic obstructive pulmonary disease (COPD) treated with inhaled corticosteroids is controversial. And some large-scale randomized controlled trials have not solved this problem. The purpose of our systematic review and meta-analysis including 44 RCTs is to reveal the effect of inhaled corticosteroids on the fracture risk of COPD patients. Methods Two reviewers independently retrieved randomized controlled trials of inhaled corticosteroids or combinations of inhaled corticosteroids in the treatment of COPD from PubMed, Embase, Medline, Cochrane Library, and Web of Science. The primary outcome was a fracture event. This study was registered at PROSPERO (CRD42022366778). Results Forty-four RCTs were performed in 87,594 patients. Inhaled therapy containing ICSs (RR, 1.19; 95%CI, 1.04–1.37; P = 0.010), especially ICS/LABA (RR, 1.30; 95%CI, 1.10–1.53; P = 0.002) and triple therapy (RR, 1.49; 95%CI, 1.03–2.17; P = 0.04) were significantly associ
Source: bmcpulmmed.biomedcentral.comCategories: General Medicine News, General Journals & SocietTweet-
Inhalation therapy containing inhaled corticosteroids significantly increases the fracture risk of patients with COPD, finds a study published #BMCPulmMed. https://t.co/jOo2mojUSQ
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Mashup Score: 2
Background The causal relationship between obesity and different allergic diseases remains controversial. Methods The Two Sample MR package and Phenoscanner database were used to obtain and filter Genome-Wide Association Study (GWAS) data from the Open GWAS database. Mendelian randomization (MR) analysis was used to study the causal relationship between different levels of obesity and different allergic diseases. The data sets related to obesity and asthma were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened by the limma package. Cluster Profiler and GO plot packages were used for enrichment analysis to verify the results of MR analysis. Results Two-sample MR analysis showed a causal relationship between obesity and childhood allergy (age < 16), allergic asthma and atopic dermatitis (P < 0.05). In addition, there was also a causal relationship between allergic asthma and obesity (P < 0.05), while there was no genetic causal
Source: bmcpulmmed.biomedcentral.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study published in #BMCPulmMed finds that obesity is a risk factor for childhood allergy and while milder obesity is related to allergic asthma, heavier obesity is causally related to atopic dermatitis. https://t.co/kyAL3XVHc5
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Mashup Score: 0
Background The causal relationship between obesity and different allergic diseases remains controversial. Methods The Two Sample MR package and Phenoscanner database were used to obtain and filter Genome-Wide Association Study (GWAS) data from the Open GWAS database. Mendelian randomization (MR) analysis was used to study the causal relationship between different levels of obesity and different allergic diseases. The data sets related to obesity and asthma were obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were screened by the limma package. Cluster Profiler and GO plot packages were used for enrichment analysis to verify the results of MR analysis. Results Two-sample MR analysis showed a causal relationship between obesity and childhood allergy (age < 16), allergic asthma and atopic dermatitis (P < 0.05). In addition, there was also a causal relationship between allergic asthma and obesity (P < 0.05), while there was no genetic causal
Source: bmcpulmmed.biomedcentral.comCategories: General Medicine Journals and Societies, Latest HeadlinesTweet-
A study published in #BMCPulmMed finds that obesity is a risk factor for childhood allergy and while milder obesity is related to allergic asthma, heavier obesity is causally related to atopic dermatitis. https://t.co/kyAL3XVHc5
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Mashup Score: 0Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer - BMC Pulmonary Medicine - 7 month(s) ago
Background Metformin is the most frequently prescribed medication for the treatment of type II diabetes mellitus and has played an anti-tumor potential in a variety of cancer types. Metformin can inhibit the growth of many cancer cells through various mechanisms, including ferroptosis. However, it is still unclear whether metformin can induce ferroptosis in lung cancer. Methods This study evaluated the anti-tumor effect of metformin by detecting the levels of oxidative stress factors, the levels of ferrous ions, and the expression of ferroptosis-related genes in A549 and H1299 lung cancer cell lines treated with or without metformin. Results The results showed that metformin treatment increased the levels of MDA, ROS and iron ions, while decreased the levels of GSH, T-SOD and CAT. Meanwhile, metformin treatment reduced the protein expression levels of Gpx4 and SLC7A11, Nrf2 and HO-1, while the addition of ferroptosis inhibitor ferrostatin-1 reversed the reduction. Conclusions These res
Source: bmcpulmmed.biomedcentral.comCategories: Healthcare Professionals, Latest HeadlinesTweet-
Metformin induces ferroptosis through the Nrf2/HO-1 signaling in lung cancer | BMC Pulmonary Medicine https://t.co/Npo0o8uypM
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Mashup Score: 0
Background Despite the evidence-based guidelines promoted by the Global Initiative for Chronic Obstructive Lung Disease (GOLD), the overuse of prescription drugs to manage COPD, particularly inhaled corticosteroids (ICS), remains a persistent challenge. In this real-world study, we evaluated how patients with COPD were divided into ABCD groups based on the 2017 GOLD guidelines, determined the rate of adherence to the GOLD treatment recommendations, described the rate of ICS usage, and determined the rate of triple therapy (TT) prescription. Methods The charts of 2291 patients diagnosed with COPD were retrospectively analyzed, of which 1438 matched the eligibility criteria. Results The average patient age was 69.6 ± 10.9 years; 52% of patients were female. The average COPD assessment test (CAT) score was 18.3 ± 9.1. The ABCD breakdown was as follows: group A 19.5%, group B 64.1%, group C 1.8%, and group D 14.6%. All groups, except group D, showed discordance in COPD treatment relative t
Source: bmcpulmmed.biomedcentral.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Gap between #Guideline recommendations of the Global Initiative for Chronic Obstructive Lung Disease (GOLD) and real-world clinical practice in #COPD care. Need for #Implementation #ImpSci #DIRH @NIH. #Overuse of inhaled #corticosteroids; #underuse of EBIs https://t.co/Apc3ZiaJ3C https://t.co/FzwiQpm9Bh
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Mashup Score: 6Characteristics of pleural effusion with a high adenosine deaminase level: a case–control study - BMC Pulmonary Medicine - 8 month(s) ago
Background Increased pleural fluid adenosine deaminase (ADA) is useful for diagnosing tuberculous pleurisy (TB), but high ADA levels are associated with other diseases. In this study, we compare various disease characteristics in patients with high-ADA pleural effusion. Methods We retrospectively collected data for 456 patients with pleural fluid ADA levels of ≥ 40 U/L from January 2012 to October 2021. Cases were classified as TB (n = 203), pleural infection (n = 112), malignant pleural effusion (n = 63), nontuberculous mycobacteria (n = 22), malignant lymphoma (ML) (n = 18), autoimmune diseases (n = 11), and other diseases (n = 27), and data were compared among those diseases. Predictive factors were identified by comparing data for a target disease to those for all other diseases. A diagnostic flowchart for TB was developed based on those factors. Results The most frequent disease was TB, though 60.0% of patients were diagnosed with other diseases. Median ADA levels in patients with
Source: bmcpulmmed.biomedcentral.comCategories: Hem/Oncs, Latest HeadlinesTweet-
Características del derrame pleural con un nivel alto de adenosina desaminasa: estudio de casos y controles. BMC Pulmonary Medicine 2022; DOI: https://t.co/zX09sknbpX https://t.co/GnTbMwdGJE
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Mashup Score: 3Idiopathic pulmonary fibrosis in the United States: time to diagnosis and treatment - BMC Pulmonary Medicine - 9 month(s) ago
Objective Create a timeline of diagnosis and treatment for IPF in the US. Design, setting, and participants A retrospective analysis was performed in collaboration with the OptumLabs Data Warehouse using an administrative claims database of Medicare Fee for Service beneficiaries. Adults 50 and over with IPF were included (2014 to 2019). Exposure To focus on IPF, the following diagnoses were excluded: post-inflammatory fibrosis, hypersensitivity pneumonitis, rheumatoid arthritis, sarcoidosis, scleroderma, and connective tissue disease. Main outcomes and measures Data were collected from periods prior, during, and following initial clinical diagnosis of IPF. This included prior respiratory diagnoses, number of respiratory-related hospitalizations, anti-fibrotic and oxygen use, and survival. Results A total of 44,891 with IPF were identified. The most common diagnoses prior to diagnosis of IPF were upper respiratory infections (47%), acute bronchitis (13%), other respiratory disease (10%)
Source: bmcpulmmed.biomedcentral.comCategories: Latest Headlines, PulmonologyTweet-
#IPF in the United States: #time to #diagnosis and #treatment https://t.co/1ipUGQEDrp https://t.co/ggrFtjdRR7
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A study published in #BMCPulmMed finds that muscle loss phenotype is common in a large population of chronic obstructive pulmonary disease (COPD) and is associated with higher risk for all-cause and COPD-related mortality. https://t.co/bj37vcjoZa