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Mashup Score: 0Cancer Research - 10 month(s) ago
Read the current issue of Cancer Research.
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Mashup Score: 0Metastasis Unleashed: Hyposialylation Empowers Chemo-Evasive Circulating Tumor Cell Clusters in Breast Cancer - 10 month(s) ago
Abstract. Therapy resistance is frequently observed in cancer patients with distant metastases and effective management of metastatic disease remains challenging. Unraveling the cellular mechanisms and molecular targets fueling metastatic spread is crucial for advancing cancer therapies. In a recent issue of Cancer Discovery, Dashzeveg and colleagues revealed that loss of terminal sialylation in…
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Online now: Read the In The Spotlight Commentary— #Metastasis Unleashed: Hyposialylation Empowers Chemo-Evasive Circulating Tumor Cell Clusters in #BreastCancer, by Nicola Aceto, discussing a recent @CD_AACR paper from @LiuCluster et al. https://t.co/Jcyrj0IaCT @ETH https://t.co/E4XRj9uVea
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Mashup Score: 0Vaccine-Boosted CAR T-cell Therapy Elicits Antigen Spreading - 10 month(s) ago
Vaccine-boosted CAR T cells induce antigen spreading to control antigenically heterogeneous tumors.
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Read this week's Cancer Discovery #ResearchWatch: Vaccine-Boosted #CARTcell Therapy Elicits Antigen Spreading, summarizing the work of @LeyuanM, Darrell Irvine et al. https://t.co/Uht7GF73u7 @kochinstitute @ragoninstitute https://t.co/SJMYU8ENEc
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Mashup Score: 4Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy - 10 month(s) ago
Tumor cells exhibit oncogene-like dependencies on specific aneuploidy events that span cancer types.
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Read this week's Cancer Discovery #ResearchWatch: Human Tumor Cells Display an Oncogene-like Addiction to Aneuploidy, a summary of the paper by @vishruth_girish, @Lakhani_AA, @JSheltzer et al. https://t.co/uBgVDZbgfe @YaleMed https://t.co/BVdf7xJLnR
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Mashup Score: 0Site-Specific Cancer Incidence by Race and Immigration Status in Canada 2006–2015: A Population-Based Data Linkage Study - 10 month(s) ago
AbstractBackground:. The Canadian Cancer Registry (CCR) does not collect demographic data beyond age and sex, making it difficult to monitor health inequalities. Using data linkage, we compared site-specific cancer incidence rates by race.Methods:. The 2006 and 2011 Canadian Census Health and Environment Cohorts are population-based probabilistically linked datasets of 5.9 million respondents of…
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Malagón et al used data linkage to study #CancerIncidence by race and immigration status in Canada and find differences between racial groups are likely influenced by differences in lifestyles, early life exposures, and selection factors for immigration. https://t.co/0yAJWuMKqr https://t.co/BOBMbWxTbz
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Mashup Score: 5Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting - 10 month(s) ago
AbstractGermline BRCA–associated pancreatic ductal adenocarcinoma (glBRCA PDAC) tumors are susceptible to platinum and PARP inhibition. The clinical outcomes of 125 patients with glBRCA PDAC were stratified based on the spectrum of response to platinum/PARP inhibition: (i) refractory [overall survival (OS) <6 months], (ii) durable response followed by acquired resistance (OS <36 months), and...
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An important #OpenAccess paper from Dr. Talia Golan & colleagues @sheba_medical in @CD_AACR Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated #PancreaticCancer in the Clinical and Preclinical Setting https://t.co/ESN1qVr11l
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Mashup Score: 2Chemotherapy Coupled to Macrophage Inhibition Induces T-cell and B-cell Infiltration and Durable Regression in Triple-Negative Breast Cancer - 10 month(s) ago
Immunostimulatory chemotherapy combined with pharmacologic inhibition of TAMs results in durable treatment responses elicited by Th cells and B cells in claudin-low TNBC models.
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#ICYMI— The June 15, 2022 issue received the most votes in our cover contest! Congrats to the authors from: #Chemotherapy/macrophage inhibition leads to TNBC regression. https://t.co/5X0bIMhlS8 @JeffMRosen @Dapedroza11 #TripleNegativeBreastCancer https://t.co/vnKFQk0cIQ
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Mashup Score: 0Reallocating Cervical Cancer Preventive Service Spending from Low- to High-Value Clinical Scenarios - 10 month(s) ago
Out-of-pocket fees are a barrier to follow-up care after an abnormal cervical cancer screening test. Among commercially insured Virginians, out-of-pocket costs for follow-up services averaged $144/patient; 34% of cervical cancer screenings were classified as low value. Reallocating low-value cervical cancer screening expenditures to enhance coverage for follow-up care can improve screening…
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July issue— Rockwell et al. show that reallocating resources from low-value #cervicalcancer spending to fund more generous coverage of necessary follow-up care is a feasible approach to enhancing cervical cancer prevention equity and outcomes. https://t.co/WfYNIYbxnV @vtcsom https://t.co/YiDuvaqZOf https://t.co/WPOqvh3Y7L
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Mashup Score: 0Resistance to selective FGFR inhibitors in FGFR-driven urothelial cancer - 10 month(s) ago
Abstract. Several FGFR inhibitors are approved or in clinical development for the treatment of FGFR-driven urothelial cancer, and molecular mechanisms of resistance leading to patient relapses have not been fully explored. We identified 21 FGFR-driven urothelial cancer patients treated with selective FGFR inhibitors and analyzed post-progression tissue and/or circulating tumor DNA (ctDNA). We…
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#ICYMI— Resistance to Selective #FGFR Inhibitors in FGFR-driven #UrothelialCancer, by Francesco Facchinetti, @Luc_Friboulet et al. https://t.co/Z9E646JlA7 @GustaveRoussy https://t.co/7yEe8HbBgS
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Mashup Score: 0
Abstract. Oncogenic point mutants of isocitrate dehydrogenases 1 and 2 (IDH2) generate 2-hydroxyglutarate (2HG), which inhibits lysine demethylases and increases heterochromatin. Tumor cells expressing IDH mutants are sensitive to poly(ADP) ribose polymerase (PARP) inhibitors, offering an opportunity to eliminate IDH-driven tumor cells in therapy. Expression of an oncogenic IDH1 mutant in cells…
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Online now: Read the In The Spotlight Commentary— Heterochromatin-dependent Replication Stress: A Lesson from IDH1/2 Mutants, by @LeeZou8 discussing a recent @MolecularCell paper from Craig Thompson et al. https://t.co/7sNg4JeTlD https://t.co/0YhXgFxQSa
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The July 15 issue is online: https://t.co/Hncat02KKT https://t.co/jqaRgeTHkp