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Mashup Score: 2Symptomatic glucocorticoid-induced adrenal suppression in the United Kingdom and Ireland: a BPSU study - 11 hour(s) ago
Objective To determine the incidence and describe the presentation and management of unexpected symptomatic glucocorticoid-induced adrenal suppression (AS) in children and young people aged 0–15 years. Setting and design Surveillance study of symptomatic glucocorticoid (GC)-induced AS with supportive biochemical evidence or presenting as an adrenal crisis, reported via the British Paediatric Surveillance Unit (BPSU) from September 2020 to September 2022. Results Over a 25-month period, 190 reports of symptomatic GC-induced AS/adrenal crisis were made, of which 22 were confirmed cases: 18 AS and 4 adrenal crises. This translates to an incidence rate of 0.09 new cases of GC-induced AS per 100 000 children aged 0–15 per year in the UK. There was a broad range of underlying diagnoses requiring GC prescription (16) and GC preparations (13). Of the 22 patients, 7 had more than 1 type of GC prescribed. The administration of oral GC occurred in 19 of the cases, inhaled GC use in 7, topical use
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Mashup Score: 1Global paediatric workforce crisis: lessons from South Korea - 8 day(s) ago
The evolution of paediatric care in South Korea has been a journey marked by both challenges and progress. In the 1950s, nascent paediatric departments at national hospitals, despite being constrained by limited resources and the aftermath of war, laid the foundation for specialised care for children.1 The early years of paediatrics in Korea, though small, were a beacon of education and clinical practice, adopting teaching methods akin to those in American medical schools and establishing a unique well-baby clinic that provided free care and immunisations. Over the following decades, paediatrics in Korea experienced significant growth and development. The Korean Paediatric Society (KPS), established in 1945, played a crucial role in advancing the field, fostering research, education and public health initiatives.2 In the early years, paediatric departments at national hospitals offered between 150 and 200 residency slots annually. This number reflected the growing demand for paediatric
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Mashup Score: 17
Objective The aim of this study was to explore parents’ views and experiences of managing preschool wheeze, including opinions on the use of investigations to inform treatment pathways. Design Purposive sampling was used to recruit 16 participants from 14 families across England and Wales. Qualitative data were collected via semi-structured interviews with parents of children aged 1–5 years with preschool wheeze, conducted on Microsoft (MS) Teams. Data were transcribed and analysed using thematic analysis, facilitated by NVivo software package. Results Analysis generated four themes: (1) pathway to diagnosis, (2) medication management, (3) living with preschool wheeze and (4) improving preschool wheeze healthcare. Findings suggest a negative impact of preschool wheeze on families’ lives, including high levels of worry and limiting capacity for work and travel. Barriers to effective management of preschool wheeze included inconsistent terminologies and diagnostic uncertainty alongside l
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Mashup Score: 4Paediatric trauma and hypocalcaemia: a systematic review - 10 day(s) ago
Background Trauma is a leading cause of mortality and morbidity in children worldwide. While adult studies have demonstrated hypocalcaemia’s association with adverse outcomes, its impact on paediatric trauma patients remains understudied. This systematic review aims to investigate current evidence into the prevalence, clinical implications and associations of hypocalcaemia in paediatric trauma. Methods A comprehensive literature search was conducted searching four databases, grey literature and additional sources for original studies looking at outcomes for paediatric trauma patients with ionised calcium measurements before blood product administration. Exclusion criteria comprised studies which included patients with blood product administration prior to calcium measurement, case reports, case series, reviews and papers not available in English. The review protocol is registered with the International Prospective Register of Systematic Reviews (PROSPERO): CRD42023432473. Data extracti
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Mashup Score: 9Management of Legg-Calve-Perthes disease: a scoping review with advice on initial management - 11 day(s) ago
Background Legg-Calve-Perthes disease (LCPD) is a developmental disorder causing avascular necrosis of the femoral head in children, with long-term consequences that can extend into adulthood. Early diagnosis and management in primary care are crucial but challenging. Aim This review aims to provide a concise overview of the presentation, differential diagnosis and management of LCPD, offering practical guidance for primary healthcare professionals. Method Recent literature and expert opinions were reviewed to summarise the epidemiology, diagnosis and current management of LCPD. Results LCPD commonly presents as a painless limp in children aged between 2 and 14 years, with the diagnosis based on the clinical features and radiographic abnormalities. Management is individualised and includes non-operative care to surgery, which attempts to correct anatomical abnormalities and therefore delay the onset of osteoarthritis. The review highlights the importance of primary care in early detect
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Mashup Score: 3
The medical examiner (ME) system was introduced in England and Wales in May 2019. Subsequently, the Health and Care Act of 2022 laid the foundations for a statutory system which was implemented on 9 September 2024. All deaths in England and Wales not investigated by a coroner are now being reviewed by a National Health Service (NHS) ME. By the end of 2023, some 2167 MEs had been trained, the majority of these are hospital consultants and general practitioners (GPs) who are supported by ME officers (MEOs) in 126 offices within NHS trusts. MEs and MEOs have undertaken specialist training for their roles facilitated by the Royal College of Pathology. The purpose of the ME system is to provide greater safeguards for the public by ensuring independent scrutiny of all non-coronial deaths, to ensure appropriate referral of deaths to the coroner, to provide a better service for the bereaved with an opportunity for them to raise any concerns to a doctor independent of the case, to improve the q
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Mashup Score: 0Increasing incidence of Kawasaki disease and associated coronary aneurysm in Aotearoa New Zealand: a retrospective cohort study - 17 day(s) ago
Background Kawasaki disease (KD) is a childhood vasculitis which causes coronary artery aneurysms (CAA). There is a paucity of data regarding KD in Aotearoa New Zealand. We aimed to provide up-to-date epidemiological and clinical data about KD in the Auckland region. Methods We conducted a retrospective population-based cohort study in the greater Auckland region between 2017 and 2021. Potential KD cases were identified from hospital discharge records, echocardiogram databases and intravenous immunoglobulin (IVIg) dispensing databases. Clinical records were reviewed and international diagnostic criteria were applied retrospectively. Results A total of 161 cases of KD were identified (66.5% complete, 33.5% incomplete), with 84% aged under 5 years. Overall incidence (per 100 000/year under 5 years) was 20.4; this was highest in Asian (43.9) and Pacific (17.7) children. There was no significant difference in incidence between New Zealand European (10.1) and Māori (8.3) children. The mean
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Mashup Score: 5Management of Legg-Calve-Perthes disease: a scoping review with advice on initial management - 20 day(s) ago
Background Legg-Calve-Perthes disease (LCPD) is a developmental disorder causing avascular necrosis of the femoral head in children, with long-term consequences that can extend into adulthood. Early diagnosis and management in primary care are crucial but challenging. Aim This review aims to provide a concise overview of the presentation, differential diagnosis and management of LCPD, offering practical guidance for primary healthcare professionals. Method Recent literature and expert opinions were reviewed to summarise the epidemiology, diagnosis and current management of LCPD. Results LCPD commonly presents as a painless limp in children aged between 2 and 14 years, with the diagnosis based on the clinical features and radiographic abnormalities. Management is individualised and includes non-operative care to surgery, which attempts to correct anatomical abnormalities and therefore delay the onset of osteoarthritis. The review highlights the importance of primary care in early detect
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Mashup Score: 2The Dutch model for regulating paediatric euthanasia - 21 day(s) ago
As of 1 February 1st, 2024, Dutch regulation allows euthanasia for children. The Netherlands was the first country to permit euthanasia. It was first permitted for adults, then for neonates in situations when a dying patient is suffering, and palliative treatments are ineffective, and now also for children. PediatricPaediatric euthanasia remains technically illegal but can be performed with minimal risk of prosecution under accepted criteria. The Dutch approach is different from other countries. In this viewpoint, we describe and analyse the Dutch model and suggests lessons that others can learn from the Dutch experience. In the Netherlands, euthanasia is defined as ‘the active ending of the life on request’. Euthanasia was first permitted in adults and children with a capacity of 12 years and older, then in infants and now is legal for children of 1–12 years. That initial approval reflected the beliefs of the Royal Dutch Medical Association (KNMG) that a doctor’s duty to preserve life
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Mashup Score: 3My gender-questioning child - 25 day(s) ago
Paediatricians, and society in general, often feel very uncertain about trajectories of gender questioning in children. Gender-questioning children have not historically been referred to paediatricians, but the new National Health Service England referral pathway as of September 2024 is that those who don’t also meet criteria for Child and Adolescent Mental Health Service referral will be seen by general paediatrics before referral to regional services.1 The Cass review of gender identity services also recommended that paediatricians with a special interest will be part of regional gender identity services.2 Paediatric endocrinologists may have an important role in considering puberty blockers or hormonal treatments. In all these ways and as leaders in child health you are important advocates for gender-questioning and transgender children’s best interests. As a parent, I wanted to tell you my child’s story so far. Not because I have any easy answers or simple actions to recommend. But
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Symptomatic glucocorticoid-induced adrenal suppression in UK and Ireland: @BPSUtweet study Luckily only 18 adrenal suppression and 4 crises over 2 years https://t.co/oczpBeAlxi