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Key Points. MH fusion impairs B-cell development and cooperates with NRASG12D mutation to trigger B-cell precursor acute lymphoblastic leukemia.MEF2D-DNA...

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    MEF2D-HNRNPUL1 fusions (poor progn in pts w B-ALL) impair B cell devel & cooperate w NRASG12D mut to trigger B-ALL; targeting fusion-driven transact of HDAC family w panobinostat + chemo had antitumour activity in mouse models of B-ALL harbouring NRASG12D: https://t.co/5M57S5UYBe - view on twitter

Recent advances in the knowledge of the pathophysiology and molecular basis of iron metabolism highlight that hemochromatosis is caused by mutations in at...

Recent advances in the knowledge of the pathophysiology and molecular basis of iron metabolism highlight that hemochromatosis is caused by mutations in at...

Key Points. Weight and height Z-scores decreased during therapy; after therapy, weight and BMI Z-scores increased but height Z-scores remained low.The...

In this issue of Blood, Petersdorf et al demonstrate a new paradigm for hematopoietic cell transplantation (HCT) donor selection that has an impact on the...

In this issue of Blood, Petersdorf et al demonstrate a new paradigm for hematopoietic cell transplantation (HCT) donor selection that has an impact on the...

Zhao Yan, Han Xiaoxu; Paranuclear blue inclusions in metastatic rhabdomyosarcoma of the bone marrow, Blood, Volume 139, Issue 20, 19 May 2022, Pages 3099,...

Key Points. In advanced stage T-cell lymphoma, the addition of etoposide to CHOP improved OS for ALK+ ALCL, but not for ALK- ALCL, AITL...

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    🗝️KEY POINTS ▪️Addition of etoposide to CHOP improved OS for ALK+ ALCL, but not for ALK- ALCL, AITL and PTCL NOS. ▪️Consolidation with ASCT in first-line significantly increased OS for ALK- ALCL, AITL and PTCL NOS 👉 https://t.co/nBnjqSEUiU 👈 #lymsm #lymphoma - view on twitter

Key Points. Real world use of tisagenlecleucel in infant B-ALL shows that this novel therapy can be effective and safe in a highly aggressive...