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Articles from: American Society of Hematology

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American Society of Hematology

Functional, structural and molecular characterizations of leukemogenic driver MEF2D-HNRNPUL1 fusion - 4 hours

Key Points. MH fusion impairs B-cell development and cooperates with NRASG12D mutation to trigger B-cell precursor acute lymphoblastic leukemia.MEF2D-DNA...

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    NatureRevClinOncol

    MEF2D-HNRNPUL1 fusions (poor progn in pts w B-ALL) impair B cell devel & cooperate w NRASG12D mut to trigger B-ALL; targeting fusion-driven transact of HDAC family w panobinostat + chemo had antitumour activity in mouse models of B-ALL harbouring NRASG12D: https://t.co/5M57S5UYBe - view on twitter

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American Society of Hematology

Hemochromatosis classification: update and recommendations by the BIOIRON Society - 10 hours

Recent advances in the knowledge of the pathophysiology and molecular basis of iron metabolism highlight that hemochromatosis is caused by mutations in at...

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American Society of Hematology

Hemochromatosis classification: update and recommendations by the BIOIRON Society - 12 hours

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Recent advances in the knowledge of the pathophysiology and molecular basis of iron metabolism highlight that hemochromatosis is caused by mutations in at...

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American Society of Hematology

Changes in body mass index, weight, and height in children with acute myeloid leukemia and the associations with outcome - 22 hours

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Key Points. Weight and height Z-scores decreased during therapy; after therapy, weight and BMI Z-scores increased but height Z-scores remained low.The...

More coverage: #clinicaltrialsandobservations #myeloidneoplasia
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American Society of Hematology

HLA-DQ + CD4 help = graft-versus-tumor effect - 23 hours

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In this issue of Blood, Petersdorf et al demonstrate a new paradigm for hematopoietic cell transplantation (HCT) donor selection that has an impact on the...

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American Society of Hematology

HLA-DQ + CD4 help = graft-versus-tumor effect - 1 day

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In this issue of Blood, Petersdorf et al demonstrate a new paradigm for hematopoietic cell transplantation (HCT) donor selection that has an impact on the...

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American Society of Hematology

Paranuclear blue inclusions in metastatic rhabdomyosarcoma of the bone marrow - 2 days

Zhao Yan, Han Xiaoxu; Paranuclear blue inclusions in metastatic rhabdomyosarcoma of the bone marrow, Blood, Volume 139, Issue 20, 19 May 2022, Pages 3099,...

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American Society of Hematology

Impact of Etoposide and ASCT on Survival Among Patients - 2 days

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Key Points. In advanced stage T-cell lymphoma, the addition of etoposide to CHOP improved OS for ALK+ ALCL, but not for ALK- ALCL, AITL...

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    Lymphoma Hub

    🗝️KEY POINTS ▪️Addition of etoposide to CHOP improved OS for ALK+ ALCL, but not for ALK- ALCL, AITL and PTCL NOS. ▪️Consolidation with ASCT in first-line significantly increased OS for ALK- ALCL, AITL and PTCL NOS 👉 https://t.co/nBnjqSEUiU 👈 #lymsm #lymphoma - view on twitter

More coverage: #lymphoma #lymsm
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American Society of Hematology

Real-World Use of Tisagenlecleucel in Infant Acute Lymphoblastic Leukemia - 3 days

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Key Points. Real world use of tisagenlecleucel in infant B-ALL shows that this novel therapy can be effective and safe in a highly aggressive...

More coverage: #bmtsm #cart #cartcell #cartcells #celltherapy #crs #gene #genetherapy #ican #immunotherapy #tcellrx
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