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Abstract. BackgroundSCD is a group of autosomal recessive red blood cell (RBC) disorders caused by a single point mutation in the β-globin gene, resulting...

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    Hoy hemos tratado a un paciente, por primera vez en España, dentro del ensayo que valora la seguridad de #crovalimab,un inhibidor de C5, en el manejo de los episodios vasooclusivos en #drepanocitosis. Contento por contribuir a la construcción de evidencia https://t.co/SLQ98BnkrQ - view on twitter

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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy with historically poor outcomes and no worldwide consensus treatment...

Key Points. Biolayer interferometry and Michaelis–Menten enzyme kinetics support the formation of the active Xase complex on lipid nanodiscs.SAXS-derived...

Key Points. Magnetic tweezers reveal a pH-dependent destabilization of the D3 interface priming VWF for multimerization by exposing Cys1099 and Cys1142.The...

Key Points. Development of a mouse carotid artery thrombolysis model of stroke.iCAT enables assessment of adjunctive antithrombotic therapies on arterial...

Key Points. Platelets lacking α4A- and β1-tubulins are devoid of marginal band and fully spherical and inefficiently interact with matrices under flow.Mice...

The most prominent morphological feature of platelets is their unusual discoid shape from which they derive their name. But why do platelets have such...