This study presents a significance analysis framework for evaluating single-cell clusters. Application of the method detects cases of over-clustering in reported single-cell RNA-sequencing analysis results.
A paper in Science reports a time-resolved multiomic atlas of the human yolk sac, expanding knowledge of this poorly resolved structure in humans.
Roohani et al. have developed a deep learning tool called GEARS that predicts the effects of multigene perturbations.
Genome-wide association studies (GWAS) have revealed important biological insights into complex diseases. The authors review approaches that leverage GWAS to identify opportunities for repurposing existing…
Carla Daniela Robles-Espinoza celebrates a paper that inspired a new generation of Mexican scientists.
2-aminothiazole — a hybrid of prebiotic amino acid and nucleotide precursors — sequentially accumulates and purifies glycolaldehyde and glyceraldehyde from complex mixtures in the order…
A general-purpose protein language model rapidly improves antibody properties.
A historical perspective on how next-generation sequencing chemistry was developed.
Regulatory circuits of gene expression can be represented as gene regulatory networks (GRNs) that are useful to understand cellular identity and disease. Here, the authors…
