Illuminating the human yolk sac through single-cell omics – Nature Reviews Genetics
A paper in Science reports a time-resolved multiomic atlas of the human yolk sac, expanding knowledge of this poorly resolved structure in humans.
Related Articles
High-throughput evaluation of genetic variants with prime editing sensor libraries
Nature Biotechnology – Prime editing sensor libraries evaluate diverse genetic variants in their endogenous genomic contexts.
Sociotechnical safeguards for genomic data privacy
Nature Reviews Genetics – In this Review, the authors describe technical and legal protection mechanisms for mitigating vulnerabilities in genomic data privacy. They also discuss…
Harnessing deep learning for population genetic inference
Nature Reviews Genetics – Applying deep learning to large-scale genomic data of species or populations is providing new opportunities to understand the evolutionary forces that…
Transposable elements in mammalian chromatin organization
Nature Reviews Genetics – This Review discusses how transposable elements contribute to mammalian genome evolution and gene regulation through their ability to both maintain and…
Microbiome epidemiology and association studies in human health
Nature Reviews Genetics – Microbiome epidemiology associates microbial community features with health outcomes, traits or exposures in human host populations. In this Review, the authors…
Amyotrophic lateral sclerosis: translating genetic discoveries into therapies
Nature Reviews Genetics – In this Review, the authors discuss our growing knowledge of the underlying genetics of amyotrophic lateral sclerosis (ALS; also known as…
Principles and methods for transferring polygenic risk scores across global populations
Nature Reviews Genetics – This Review summarizes the genetic and non-genetic factors that impact the transferability of polygenic risk scores (PRSs) across populations, highlighting the…
Unraveling the functional dark matter through global metagenomics
Nature – A computational approach to generate reference-free protein families from the sequence space in metagenomes reveals an enormously diverse functional space.
Newborn Genomic Screening Needs to Build the Evidence
With many large newborn genomic screening studies launching, we need to answer questions about cost, fairness and tangible benefits of a promising technology