Recent evidence derived from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), shows a direct correlation between the severity of systemic inflammation, progression to respiratory failure, and fatal outcome.1 The appearance of clinical signs of severe pneumonia is associated with progressive and persistent elevation of D-dimer and…
Studies have linked daily pollen counts to respiratory allergic health outcomes, but few have considered allergen levels.We sought to assess associati…
Type 2 inflammation is characterized by overexpression and heightened activity of type 2 cytokines, mediators, and cells that drive neuroimmune activa…
The use of human antibodies as biologic therapeutics has revolutionized patient care throughout fields of medicine. As our understanding of the many r…
Food allergy is a growing public health issue among children and adults that can lead to life-threatening anaphylaxis following allergen exposure. The…
The allergen-IgE interaction is essential for the genesis of allergic responses, yet investigation of the molecular basis of these interactions is in …
Treatment options for itch are limited. Antihistamines represent the most widely available class of antipruritic drugs, with over $2 billion in sales per year for…
Chronic rhinosinusitis with nasal polyps (CRSwNP) causes nasal obstruction and olfactory dysfunction. Aspirin-exacerbated respiratory disease (AERD) i…
Urticaria is characterized by inappropriate mast cell degranulation leading to the development of wheals and/or angioedema. Twin and family studies in…
Germinal center (GC) responses controlled by T follicular helper (Tfh) and T follicular regulatory (Tfr) cells are crucial for the generation of high-…
The immunogenicity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccines is variable in individuals with different inborn erro…
