PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization
Ito et al. highlight peroxiredoxin 6 (PRDX6) as a critical regulator of ferroptosis. As a selenium-acceptor protein, PRDX6 aids in intracellular selenium utilization for efficient selenoprotein biosynthesis, including glutathione peroxidase 4 (GPX4), the guardian of ferroptosis. PRDX6-deficiency reduces GPX4 expression levels in the mouse brain and increases tumor sensitivity to ferroptosis, underscoring its physiological significance.
