Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologies
A family of ENGases secreted by corynebacterial species strictly targeting the Asn297-linked glycan on human IgG antibodies was discovered. The prototypical family member, CU43, demonstrated remarkable efficacy in treating pathologies that rely on Fc γ receptor (FcγR)-mediated effector functions, including T and B lymphocyte depletion, autoimmune hemolytic anemia, and antibody-dependent enhancement of dengue disease activity.