SARS-CoV-2 viral proteins interact with the eukaryotic translation machinery and inhibitors of translation have potent antiviral effects. Here we report that the drug plitidepsin (aplidin), which has limited clinical approval, possesses antiviral activity (IC90 = 0.88 nM) 27.5-fold more potent than remdesivir against SARS-CoV-2 in vitro, with limited toxicity in cell culture. Through the use of a…
Noise pollution is expanding at an unprecedented rate and is increasingly associated with impaired reproduction and development across taxa. However, whether noise sound waves are…
A deep learning–based real-time detection system improves the detection rate of high-risk esophageal lesions.
Soil microbiota from stressful environments provide an avenue for climate resilience
Intrinsically safe designs and a staged transparent development process will be essential
Drugs of abuse are thought to promote addiction in part by “hijacking” brain reward systems, but the underlying mechanisms remain undefined. Using whole-brain FOS mapping…
Highly deformable platelet-like particles mitigate bleeding, improve healing responses, and exhibit renal clearance in small and large animal models.
A new biography celebrates the Spaniard who founded modern neuroscience
Adiposity subtypes are associated with colorectal cancer through genetic variants enriched in the brain and adipose tissue.
Overlooked by the oil industry, natural hydrogen could power society for thousands of years
