Phylogenomic characterization and signs of microevolution in the 2022 multi-country outbreak of monkeypox virus

The largest monkeypox virus (MPXV) outbreak described so far in non-endemic countries was identified in May 20221-6. Here, shotgun metagenomics allowed the rapid reconstruction and phylogenomic characterization of the first MPXV outbreak genome sequences, showing that this MPXV belongs to clade 3 and that the outbreak most likely has a single origin. Although 2022 MPXV (lineage B.1) clustered…

Read the full article here

Source: www.nature.com

Categories: General Medicine Journals and Societies, Latest Headlines

Tweets with this article

Nature Portfolio

The strain associated with the current monkeypox outbreak is a well-defined divergent branch from the monkeypox viruses of a 2018–19 outbreak in an endemic country that probably represents recent evolutionary changes, according to a @NatureMedicine paper. https://t.co/HKvspHwNbR https://t.co/5HzrFB1Gpn

Related Articles

Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders

Nature Biotechnology – Peroxides localized at oxidative stress sites trigger prodrug release for treating chronic pain in mice.

Nature Biotechnology November 4, 2024

A cost-effective climate mitigation pathway for China with co-benefits for sustainability

Nature Communications – Climate mitigation have broad effects on achieving Sustainable Development Goals. This paper explores the spillover effects of China’s climate mitigation pathways and…

Nature Communications November 4, 2024

Early emergence and determinants of human-induced Walker circulation weakening

Nature Communications – This study shows that human-induced weakening of the Walker Circulation tends to occur earlier in the middle-upper troposphere than at the surface,…

Nature Communications November 4, 2024

The value of long-duration energy storage under various grid conditions in a zero-emissions future

Nature Communications – This study models a zero-emissions Western North American grid to provide guidelines and understand the value of long-duration storage as a function…

Nature Communications November 4, 2024

Atmospheric health burden across the century and the accelerating impact of temperature compared to pollution

Nature Communications – For different future scenarios, end-of-century mortality could quadruple from present day values. Importantly, the non-optimal temperature attributable mortality will…

Nature Communications November 4, 2024

Characterization of the B cell receptor repertoire in melanoma

Nature Reviews Cancer – In this Journal Club, Chae and Chung discuss a study characterizing the differentiation and maturation of both tumour-resident and circulating B…

NatureReviewsCancer November 4, 2024

Selected social impact indicators influenced by materials for green energy technologies

Nature Communications – This study identifies materials used in green energy technologies with the most social benefits and risks. Aluminum production creates the most jobs…

Nature Communications November 4, 2024

A pathogenic role for IL-10 signalling in capillary stalling and cognitive impairment in type 1 diabetes

Nature Metabolism – Interleukin-10 promotes the formation of microcirculatory defects in the brain associated with cognitive impairment in a mouse model of type 1 diabetes.

Eric Topol November 4, 2024

Parkinson disease therapy: current strategies and future research priorities

Nature Reviews Neurology – Parkinson disease (PD) poses substantial management challenges owing to progressive disability and emergence of levodopa-resistant symptoms and treatment-related…

Nat Rev Neurology November 4, 2024

Cell therapy for neurological disorders

Nature Medicine – This Review summarizes the state of clinical research on cell replacement therapy for neurological conditions, and discusses the challenges facing the field,…

Nature November 4, 2024