Parallel evolution at the regulatory base-pair level contributes to mammalian inter-specific differences in polygenic traits.
Parallel evolution occurs when distinct lineages with similar ancestral states converge on a new phenotype. Parallel evolution has been well documented at the organ, gene pathway, and amino-acid sequence level but in theory it can also occur at individual nucleotides within non-coding regions. To examine the role of parallel evolution in shaping the biology of mammalian complex traits, we used data on single nucleotide polymorphisms (SNPs) influencing human intraspecific variation to predict trait values in other species for eleven complex traits. We found that the alleles at SNP positions associated with human intraspecific height and red blood cell count variation are associated with interspecific variation in the corresponding traits across mammals. These associations hold for deeper branches of mammalian evolution as well as between strains of collaborative cross mice. While variation in red blood cell count between primates uses both ancient and more recently evolved genomic regio