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The Xist RNA protein complex, present only in females, is immunogenic and may underlie female-biased autoimmunity.
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Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling pathways in immune cells. Notable examples include succinate and itaconate, which have pro- and…
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We report on the relationship between leukocyte telomere length (LTL), genetics, and environmental factors in ethnically diverse Africans. LTL is longer in African ancestry individuals…
Cell Press: STAR Protocols
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all…
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OA was generally considered as a non-inflammatory disease dominated by articular cartilage degeneration. However, the role of synovitis in OA pathogenesis has received increasing attention.…
Spermidine – an old molecule with a new age-defying immune function
Polyamines – putrescine, spermidine, and spermine – are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine…
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The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its…
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Potential corporate uses of polygenic indexes: Starting a conversation about the associated ethics and policy issues
Despite the relative noisiness of polygenic indexes (PGIs), some commercial firms will use them. We offer a simple model, rooted in economic theory, to show…