OHSU research offers clues for potential widespread HIV cure in people
New study reveals first details on how stem cell transplantation can kill virus that causes AIDS.
Related Articles
COVID-19 and Asthma Onset in Children
BACKGROUND AND OBJECTIVES:. Respiratory viral infections increase risk of asthma in infants and children. Infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus…
The role and impact of viruses on cancer development
This review focuses on three major aspects of oncoviruses’ role in cancer development. To begin, we discuss their geographic distribution, revealing that seven oncoviruses cause…
Interferon-induced transmembrane protein-1 competitively blocks Ephrin receptor A2-mediated Epstein–Barr virus entry into epithelial cells
Nature Microbiology – IFITM1 can compete with EBV glycoproteins for EphA2 binding and prevent virus entry into epithelial cells, in vitro and in vivo. YTHDF3…
Inflammation and cytomegalovirus viremia during pregnancy drive sex-differentiated differences in mortality and immune development in HIV-exposed infants
Nature Communications – HIV exposed but uninfected infants may face an increased risk of serious infection and mortality. In this work, the authors utilise a…
SARS-CoV-2 nsp15 preferentially degrades AU-rich dsRNA via its dsRNA nickase activity
Abstract. It has been proposed that coronavirus nsp15 mediates evasion of host cell double-stranded (ds) RNA sensors via its uracil-specific endoribonuclea
Myeloid C-type lectin receptors in innate immune recognition
C-type lectin receptors (CLRs) comprise a vast family of proteins, several of which play key roles in the immune system. In this article, Reis e…
Enteric coronavirus nsp2 is a virulence determinant that recruits NBR1 for autophagic targeting of TBK1 to diminish the innate immune response
Non-structural protein 2 (nsp2) exists in all coronaviruses (CoVs), while its primary function in viral pathogenicity, is largely unclear. One such enteric CoV, porcine epidemic…
New drug prevents flu-related inflammation and lung damage
Findings show a newly created drug can prevent runaway inflammation while still allowing the immune system to handle the virus, even when given late into…
MEF2C regulates NK cell effector functions through control of lipid metabolism
Nature Immunology – Here the authors identify the transcription factor MEF2C as essential for human NK cell function and viral immunity in mice and humans.…