Novel injectable agent lowers Lp(a) by more than 80% at 36 weeks
CHICAGO — Zerlasiran, a novel injectable small interfering RNA molecule, lowered lipoprotein(a) by more than 80% compared with placebo at 36 weeks, according to the results of the ALPACAR trial.The phase 2 ALPACAR trial, results of which were presented at the American Heart Association Scientific Sessions and simultaneously published in JAMA, included 178 patients (mean age, 63.7 years;