Major histocompatibility complex class I deficiency results from deleterious biallelic variants in TAP1, TAP2, TAPBP, and B2M genes. Only a few patients with variant-curated TAP1 deficiency (TAP1D) have been reported in the literature and the clinical phenotype has been variable with an emphasis on …
“This Patient Needs a Doctor, Not a Guideline!” The Zone of Uncertainty in Pulmonary Arterial Wedge Pressure Measurement
A highly conserved motif in human PD-1 but absent in rodent PD-1 is linked to differential inhibitory activity.
The study highlights T2-low and T17-high asthma endotypes in minoritized youths, offering insights for precision medicine and improved asthma management.
Understanding the risk factors leading to severe systemic sting reactions (SSRs) is crucial for initiating venom immunotherapy (VIT) and for educating affected individuals and their…
Nature Reviews Immunology – This Perspective discusses current knowledge of the diverse roles played by different macrophage populations within the Mycobacterium tuberculosis-infected lung. The…
Lanadelumab was well tolerated and effective in preventing hereditary angioedema (HAE) attacks in the phase 3, double-blind, placebo-controlled Hereditary angioEdema Long-term Prophylaxis (HELP) study and…
Diverse macrophage populations inhabit the rodent and human central nervous system (CNS), including microglia in the parenchyma and border-associated macrophages (BAMs) in the meninges, choroid…
A patient, aged 68, admitted to the Internal Medicine Ward, in connection with syncope and a persisting fever which had appeared for the third time…
SABR shows excellent long-term disease control for low- and intermediate-risk localized prostate cancer. Patients treated for prostate cancer have a moderate risk of SM, consistent…
