Neoself-antigens are the primary target for autoreactive T cells in human lupus
The discrimination of self- and neoself-antigens by T cells plays a crucial role in the activation of autoreactive T cells, leading to the development of autoimmunity. The reactivation of the Epstein-Barr virus is a possible factor that causes MHC class II molecules to present neoself-antigens by decreasing the expression of the invariant chain.