Murine MHC-Deficient Nonobese Diabetic Mice Carrying Human HLA-DQ8 Develop Severe Myocarditis and Myositis in Response to Anti–PD-1 Immune Checkpoint Inhibitor Cancer Therapy
Key Points. NOD-cMHCI/II−/−.DQ8 mice are susceptible to ICI-induced lethal myocarditis/myositis.T cells from heart or skeletal muscles are capable of targe