Menin inhibitors in the treatment of acute myeloid leukemia
In this Blood Spotlight, Huls et al highlight why small molecule inhibitors of menin are creating excitement in the acute myeloid leukemia (AML) field with
In this Blood Spotlight, Huls et al highlight why small molecule inhibitors of menin are creating excitement in the acute myeloid leukemia (AML) field with
A virtual Patient Advocate Forum presented by the AACR explored the potential for new ways to design patient-centric cancer clinical trials.
Key PointsSY-5609 repressed Myc, inhibited cell growth, induced lethality, and depleted protein expressions in post-MPN sAML stem/progenitor cells.SY-5609
In the phase 2 TRANSCEND FL trial, lisocabtagene maraleucel met its primary end point of overall response rate in patients with marginal zone lymphoma.
The ENGOT-cx11/GOG-3047/KEYNOTE-A18 randomized controlled trial demonstrated an overall survival benefit in cervical cancer patients treated with pembrolizumab during and after chemoradiotherapy as c…
The Christie NHS Foundation Trust has created a supportive oncology program to train fellows and offer services for patients living with cancer.
Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning…
MajesTEC-5 is a phase II trial evaluating teclistamab in combination with DR, with or without bortezomib, for NDMM. During ASH 2024, Marc Raab presented initial…
Continuous advancements in cancer management have resulted in increased long-term survival rates amongst cancer survivors and in turn have exposed the full extent of radiotherapy-associated…
Paolo Tarantino, MD, PhD, discusses the approval of the oral therapy elacestrant for patients with estrogen receptor-positive, HER2-negative advanced or metastatic breast cancer with ESR1…
Sacituzumab govitecan (SG), a Trop-2-directed antibody–drug conjugate, demonstrated efficacy and manageable toxicity in the phase II TROPHY-U-01 study in pretreated advanced urothelial carcinoma (aUC). We…