Márta Korbonits talks with The Lancet Diabetes & Endocrinology about mechanisms of ageing: growth hormone, dietary restriction, and metformin.Read the full article:Mechanisms of ageing: growth hormone, dietary restriction, and metformin
Melatonin, a hormone primarily produced by the brain’s pineal gland, is typically secreted during darkness, aligning with the time when most people sleep. Melatonin plays…
With up to 23 years of follow-up of three large prospective cohorts of middle-aged and older men and women, self-reported melatonin supplement use was not…
Phaeochromocytomas and paragangliomas (PPGLs) release catecholamines leading to catecholamine-induced hypertensive (CIH) crises, with blood pressure greater than or equal to 180/120 mm Hg. CIH crises…
Congenital hypogonadotropic hypogonadism (CHH) is caused by abnormal gonadotropin secretion or action. Although rare, CHH is approximately twice as common in men than in women.1,2…
Applying LCMM to a large cohort of male patients with CHH reversal uncovered two distinct classes of reversal. Genetic investigation combined with careful clinical phenotyping…
Launched as a public–private partnership funded by the Foundation for the National Institutes of Health, the Study to Advance Bone Mineral Density as a Regulatory…
With the increase in obesity prevalence worldwide, considerable efforts have been made to investigate the molecular and neurohormonal mechanisms of bodyweight control, as a means…
These findings support setmelanotide as a novel effective treatment of hypothalamic obesity.
In pregnant women starting with tighter glycaemic control, AHCL therapy did not improve overall time in target range but improved overnight time in target range,…
The role of hybrid closed-loop systems in the clinical management of type 1 diabetes is rapidly expanding. Randomised controlled trials have shown life-changing clinical and…
