Loss of LPAR6 and CAB39L dysregulates the basal-to-luminal urothelial differentiation program, contributing to bladder carcinogenesis
Lee et al. report that FR genes mapping near RB1 are associated with the development of field effects initiating bladder carcinogenesis. Two of these genes are distinctively downregulated in luminal and basal cancers. Their loss contributes to carcinogenesis by dysregulating urothelial differentiation mediated by cholesterol and the unfolded protein reaction.