Kinetics of Beta2-Microglobulin with Hemodiafiltration and… : Clinical Journal of the American Society of Nephrology
emodialysis. The impact of hemodiafiltration on beta-2-microglobulin levels was evaluated by modeling four randomized studies of hemodiafiltration vs. hemodialysis. The impact of residual kidney function on beta-2-microglobulin was tested by comparing results of previously reported measured data with model predictions. Results: In the low-flux and high-flux arms of the HEMO study, measured median beta-2-microglobulin reduction ratios could be matched by dialyzer clearances of 5.2 and 26 ml/min, respectively. Median pre-dialysis serum beta-2-microglobulin levels were matched if generation rates of beta-2-microglobulin were set to approximately 240 mg/day. In another group of patients treated with dialyzers with increased beta-2-microglobulin clearances, measured cross-dialyzer clearances (57±28 ml/min) were used as inputs. In these studies the kinetic model estimates of intradialysis and early postdialysis serum beta-2-microglobulin levels were similar to median measured values. The mod