IL-22Ra2 Levels Remain Elevated in People with Cystic Fibrosis despite Modulator Therapy
Chronic bacterial infection within the lung and airway is a hallmark of cystic fibrosis (CF) and the leading driver of morbidity and mortality. With the introduction of highly effective CF transmembrane conductance regulator (CFTR) protein modulator therapy, there have been conflicting reports on the extent of sustained infection and inflammat ion reduction (1 – 3). Understanding aberrant host defense against chronic sinopulmonary infections remains an area of intense interest in CF. In the CF airway and
