Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization
Pronounced necrosis in glioblastomas is accompanied by abundant destabilized microvessels. Wang et al. show that the niche cues from the peri-necrotic regions polarize macrophages toward a hypoxic state, which in turn augments vascular hyperpermeability. Targeting adrenomedullin produced by hypoxic macrophages normalizes tumor neovasculature and improves anti-tumor drug delivery and efficacy.