Helping behavior is associated with increased affiliative behavior, activation of the prosocial brain network and elevated oxytocin receptor expression in the nucleus accumbens
A prosocial response to others in distress is increasingly recognized as a natural behavior for many social species, from humans to rodents. While prosocial behavior is more frequently observed towards familiar conspecifics, even within the same social context some individuals are more prone to help than others. For instance, in a rat helping behavior test, rats can release a distressed conspecific trapped inside a restrainer by opening the restrainer door. Typically, rats are motivated to release a trapped cagemate, and consistently release the trapped rat (‘openers’), yet around 30% do not open the restrainer (‘non-openers’). To characterize the difference between these populations, behavioral and neural activity were compared between opener and non-opener rats tested with a trapped cagemate in the helping test. Behaviorally, openers showed significantly more social affiliative behavior both before and after door-opening compared to non-openers. Analysis of brain-wide neural activity