Heart Failure With Preserved Ejection Fraction in Females: An Arterial Disease
Author links open overlay panel Rebecca Crosier MD a, Thais Coutinho MD b As humans age, elastic fibres in the aorta’s tunica media succumb to repetitive pulsatile stress, leading to g radual fracture and rarefaction of the fibres. Over time, collagen—a tensile fibre—is deposited instead, resulting in increased aortic stiffness, and decreased aortic ability to buffer the pulsatile pressure generated by the beating left ventricle. However, there are sex differences in arterial aging, with older females