FDA accepts IND for allogenic CAR T-cell therapy that could bypass lymphodepletion
The FDA has accepted an investigational new drug application for ALLO-329, an allogeneic chimeric antigen receptor T-cell therapy that may bypass lymphodepletion, paving the way for a phase 1 trial in lupus and other autoimmune diseases. The trial will involve the use of Allogene Therapeutics’ Dagger technology, which aims to reduce, or avoid entirely, the need for pre-treatment