Emotional stress increases GluA2 expression and potentiates fear memory via adenylyl cyclase 5
Yang et al. reveal that AC5 in cerebellar interneurons drives a stress and norepinephrine-induced increase in synaptic GluA2 expression via a PKA-CREB pathway. Deletion of AC5 abolishes the enhancement of fear memory after stress. This highlights the importance of AC5 in both interneuron plasticity and fear memory potentiation.