Effectiveness of COVID-19 vaccines against Omicron or Delta symptomatic infection and severe outcomes

Background The incidence of SARS-CoV-2 infection, including among those who have received 2 doses of COVID-19 vaccines, increased substantially following the emergence of Omicron in Ontario, Canada. Methods Applying the test-negative study design to linked provincial databases, we estimated vaccine effectiveness (VE) against symptomatic infection and severe outcomes (hospitalization or death)…

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