Disease-specific suppressive granulocytes participate in glioma progression
Zhao et al. report the identification and characterization of immunosuppressive neutrophils within human and mouse glioma tumors. The presence of such disease-specific suppressive granulocytes (DSSGs) correlates with glioma grades and poor clinical outcomes. Blockage of DSSGs, which partly originate from the skull bone marrow and meninges, strongly delays tumor progression.