Differential landscape of immune evasion in oncogenic RAS-driven primary and metastatic colorectal cancers
Lou and colleagues report a comprehensive analysis of 7,801 cases of colorectal cancer (CRC). They discovered significant differences in the tumor inflammatory microenvironment associated with the oncogenic driver KRAS, uncovering signatures of immunoevasive capacity. There were no significant differences in prevalence of KRAS in young adults in this cohort.