Designed mosaic nanoparticles enhance cross-reactive immune responses in mice
Computational methods were used to design mosaic nanoparticle vaccines displaying receptor-binding domains of SARS-CoV-2 variants and sarbecoviruses. Immunization of naive and pre-vaccinated mice elicited more potent cross-reactive antibody responses against SARS-CoV-2 variants and sarbecoviruses with spillover potential compared with previous nanoparticles.