Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T cell interactions
COVID-19 can cause severe neurological symptoms. By deep spatial analysis of post-mortem brain tissue, Schwabenland, Salie et al. identify accumulation of distinct microglial and T cell subsets in microglial nodules and the perivasculature. They observe neuroinflammation with axonal damage, virus-associated perivascular inflammation and compromised blood-brain-barrier. This profound…
