Deconstructing the neural circuit underlying social hierarchy in mice
Xin et al. find that in the dorsomedial prefrontal cortex (dmPFC), layer 2/3 neurons projecting to the anterior basolateral amygdala promote losing, whereas layer 5 neurons projecting to the dorsal raphe nucleus and periaqueductal gray promote winning. Moreover, the lose-related pathway inhibits the win-related pathways through local GABAergic interneurons.