Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion
The balance of T cells in a progenitor-exhausted state and those in a terminally exhausted state is a critical determinant of anti-tumor responses. Waibl Polania, Hoyt-Miggelbrink, et al. identify antigen presentation and tumor-associated macrophages (TAMs) as key drivers of counterproductive skews toward terminal exhaustion in solid tumors. TAM depletion restores this balance and enhances immunotherapeutic responses.
