Patel and Helmann identify metabolic pathways that are dysregulated in RNAP mutant strains with altered β-lactam sensitivity. Genetic and physiological studies demonstrate that BCAA and Pyr synthesis are repressed in a β-lactam-resistant strain. Derepression of these pathways, genetically or by β-lactams, leads to ROS production and antibiotic sensitivity.
A US spy plane flew over the Gulf of California in Mexico this week. The purpose of the flight is unusual, but it comes at…
Vivien Thomas helped develop what’s long been known as the Blalock-Taussig shunt. More prominent recognition of his vital contribution is way overdue.
International Stroke Congress (ISC) Articles | JAMA Network International Stroke Conference (ISC) QUICK LINKS: Visit Us at ISC For Authors More Articles QUICK LINKS Visit…
International Stroke Congress (ISC) Articles | JAMA Network International Stroke Conference (ISC) QUICK LINKS: Visit Us at ISC For Authors More Articles QUICK LINKS Visit…
There’s a nationwide effort to better prepare undergrad medical students for the clinical experience.
Short email from a longtime colleague, working in Africa at a PEPFAR site: Without USAID, PEPFAR is essentially dead. I got chills reading this. PEPFAR, the abbreviation for…
Mayo Clinic, Mount Sinai and Huntsman Cancer Insitute are delivering services from chemotherapy to imaging in cancer patients’ homes.
Gene editing promised a revolution, but biotech layoffs, stock slumps, and industry struggles reveal a stark reality: CRISPR is hard to do profitably.
EurekAlert! is an online science news service featuring health, medicine, science and technology news from leading research institutions and universities. Sponsored by AAAS, the science…
Objective Quantify insulin glargine prices following the market introduction of biosimilars. Examine price levels and price changes for originator and biosimilars, by country. Methods Retrospective…
