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Tricarboxylic acid (TCA) cycle metabolites have been implicated in modulating signalling pathways in immune cells. Notable examples include succinate and itaconate, which have pro- and…
Association between telomere length and Plasmodium falciparum malaria endemicity in sub-Saharan Africans
We report on the relationship between leukocyte telomere length (LTL), genetics, and environmental factors in ethnically diverse Africans. LTL is longer in African ancestry individuals…
Cell Press: STAR Protocols
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all…
Identification and validation of immune-related genes in osteoarthritic synovial fibroblasts
OA was generally considered as a non-inflammatory disease dominated by articular cartilage degeneration. However, the role of synovitis in OA pathogenesis has received increasing attention.…
Spermidine – an old molecule with a new age-defying immune function
Polyamines – putrescine, spermidine, and spermine – are widely distributed aliphatic compounds known to regulate important biological processes in prokaryotic and eukaryotic cells. Therefore, spermidine…
Immune cell-derived signals governing epithelial phenotypes in homeostasis and inflammation
The intestinal epithelium fulfills important physiological functions and forms a physical barrier to the intestinal lumen. Barrier function is regulated by several pathways, and its…
Epigenome-wide meta-analysis of BMI in nine cohorts: Examining the utility of epigenetically predicted BMI
DNA methylation is increasingly used as a biomarker of health and associates with BMI. Do et al. constructed an epigenetic BMI score and observed differential metabolic…
Potential corporate uses of polygenic indexes: Starting a conversation about the associated ethics and policy issues
Despite the relative noisiness of polygenic indexes (PGIs), some commercial firms will use them. We offer a simple model, rooted in economic theory, to show…
Massively parallel reporter assay confirms regulatory potential of hQTLs and reveals important variants in lupus and other autoimmune diseases
A massively parallel reporter assay (MPRA) characterizes the potential for histone post-translational modifications (i.e., histone quantitative trait loci [hQTLs]) to modulate regulatory activity and uncovers…
Variation in ERAP2 has opposing effects on severe respiratory infection and autoimmune disease
The T allele at the ERAP2 SNP rs2549794 has been suggested as deleterious during the Black Death. We have found that the T allele is…