Ischemic stroke and vascular cognitive impairment are global health threats. Recent research has uncovered a previously underappreciated dynamic interplay between brain-resident, meningeal, and systemic immune cells. Iadecola and Anrather discuss the neurovascular immune factors that play a central role in the overlap between neurovascular pathologies and Alzheimer’s disease and in the complications associated with Aβ immunotherapy for Alzheimer’s.
The mechanisms underlying synergy between checkpoint blockade and anti-angiogenic therapy remain elusive. In this issue of Cancer Cell, Guo et al. analyze hepatocellular carcinoma patients treated…
Guo et al. trace immune cell dynamics in patients with hepatocellular carcinoma (HCC) receiving neoadjuvant anti-PD-1 plus lenvatinib by single-cell multi-omics technologies. Compared with anti-PD-1 monotherapy,…
The adaptor protein mitochondrial antiviral signaling protein (MAVS)-mediated innate immune response is essential for host defense against RNA viruses. Gokhale and colleagues report that cellular…
Tumor-infiltrating regulatory T (TI-Treg) cells constitute key components within the tumor microenvironment (TME) to suppress antitumor immunity and facilitate tumor progression. Although multiple therapies have…
The human immune system contains a vast repertoire of somatically recombined T cell receptor (TCR) sequences. To connect TCR sequence to T cell function, Lagattuta et al. analyze…
Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate…
The AAAAI offers articles written and reviewed by experts on allergy, asthma, immune deficiencies. In this article we review food allergies, youth & alcohol
The lack of well-defined indirect CD4+ T cell epitopes has hindered mechanistic studies and the development of antigen-specific tolerance strategies in transplantation. Zhanzak et al. identify donor-derived…
The mechanisms underlying synergy between checkpoint blockade and anti-angiogenic therapy remain elusive. In this issue of Cancer Cell, Guo et al. analyze hepatocellular carcinoma patients treated…
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