Lactate elevations are a hallmark of human disease, but the mechanisms regulating lactate levels remain poorly understood. Here, Lee et al. elucidate the mechanisms of lactate homeostasis. These involve lactate feedback inhibiting its own production by impairing muscle insulin signaling and insulin driving lactate consumption.
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Hypertension is a global health problem with an estimated prevalence of 32% worldwide and increasing.1 In fact, hypertension is the most common modifiable risk factor…
Ischemic stroke and vascular cognitive impairment are global health threats. Recent research has uncovered a previously underappreciated dynamic interplay between brain-resident, meningeal, and systemic immune…
The offerings reflect an increase in IPO activity that could continue, as four other biotechs recently outlined plans to go public.
Guo et al. trace immune cell dynamics in patients with hepatocellular carcinoma (HCC) receiving neoadjuvant anti-PD-1 plus lenvatinib by single-cell multi-omics technologies. Compared with anti-PD-1 monotherapy,…
New data from US centers suggest some overtesting in patients without chest pain, and undertesting in those who do.
— JOURNAVX is the first and only approved non-opioid oral pain signal inhibitor and the first new class of pain medicine approved in more than…
We’re thrilled to announce Season 2 of The Digital Healthcare Experience! Setting the bar high with Dr. Ami Bhatt, Chief Innovation Officer at the American…
